2010 Fiscal Year Final Research Report
Higher-order genomic structure and subcellular organization
| Project/Area Number |
19207001
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKEYASU Kunio Kyoto University, 大学院・生命科学研究科, 教授 (40135695)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Shigehiro 京都大学, 大学院・生命科学研究科, 准教授 (90346106)
HIDUME Kouji 京都大学, 大学院・生命科学研究科, 助教 (10378846)
ATOMI Haruyuki 京都大学, 大学院・工学科学研究科, 准教授 (90243047)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ゲノム構築 / 機能 / 再編 / 発現 / 維持 |
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| Research Abstract |
(1) In Archaea, TK0471 is a structural protein as well as a transcription factor. (2) Nucleolar proteins (MAk16, WD46, MAGEFF, FAM27E1, etc.) with unknown function move very slowly compared to the well-known nucleolar proteins. They behave also very differently in the presence of transcription inhibitor, actinomycin D. (3) A cytoskeletal protein, actinin-4, shuttles between cytoplasm and nuclelar plasm, dependent of cell cycle and independent on importin-β.
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[Journal Article] Histone and TK0471/TrmBL2 form a novel heterogeneous genome architecture in the hyperthermophilic archaeon Thermococcus kodakarensis.2010
Author(s)
H.Maruyama, Minsang Shin , T.Oda , Rie Matsumi , R.L.Ohniwa , T.Itoh , K.Shirahige , T.Imanaka , H.Atomi , Shige H.Yoshimura , K.Takeyasu
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Journal Title
Mol.Biol.Cell 22
Pages: 386-398
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