Molecular basis of the survival strategy via autophagy

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19207015
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: YOSHIMORI Tamotsu Osaka University, 微生物病研究所, 教授 (60191649)
• Project Period (FY): 2007 – 2010
• Keywords: 細胞構造・機能 / メンブレントラフィック

Research Abstract

オートファジーは、真核生物に普遍的な細胞内大規模分解システムとして、飢餓時の栄養源確保から病原体排除まで多彩な機能を持つ。これらの機能の多くは生命維持に関わっており、オートファジーの多面的活用による生存戦略が存在するといえよう。オートファジーの役割の解明が進む一方で、その分子機構はいまだ謎が多い。本研究課題では、生存戦略としてのオートファジーという観点からその分子解剖を行う。

Research Products

• [Journal Article] An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7 (2009)
  • Author(s): Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T
  • Journal Title: PLoS Pathog. 5(11) Pages: e1000670
  • URL: doi:10.1371/journal.ppat.1000670
  • Peer Reviewed
• [Journal Article] A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation (2009)
  • Author(s): Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A
  • Journal Title: Nat Cell Biol. 11 Pages: 1433-1437
  • Peer Reviewed
• [Journal Article] Two Beclin-1 binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009)
  • Author(s): Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda, K, Ichimura I, Isobe T, Akira S, Noda T, Yoshimori T
  • Journal Title: Nature Cell Biol. 11 Pages: 385-396
  • Peer Reviewed
• [Presentation] Binding Rubicon to Cross the Rubicon EMBO Conference on : Autophagy, Cell Biology (2009)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Physiology and Pathology Monte Verita
  • Place of Presentation: Ascona, Switzerland
  • Year and Date: 20091018-20091021
• [Presentation] Where they come from? : Mechanistic insight into autophagosome formation in mammals (2008)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference "Autophagy In Stress, Development And Disease" Ventura
  • Place of Presentation: CA, USA
  • Year and Date: 20080106-20080111
• [Remarks] ホームページ
  • URL: http://www.saibouseigyo.com/jp/