2010 Fiscal Year Final Research Report
Mechanisms for regulation of lymphangiogenesis
| Project/Area Number |
19209009
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
MIYAZONO Kohei The University of Tokyo, 大学院・医学系研究科, 教授 (90209908)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WATABE Tetsuro 東京大学, 大学院・医学系研究科, 准教授 (00334235)
IWATA Caname 東京大学, 大学院・医学系研究科, 助教 (50511391)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | シグナル伝達 / 病理学 / 発生・分化 / 癌 |
|---|
| Research Abstract |
In order to elucidate the mechanisms of lymphangiogenesis, we have studied the action of Prox1, a master regulator of lymphangiogenesis. In this project, we have found that TGF-beta represses the expression Prox1, whereas HoxD8 induces it. In the nucleus, Prox1 was shown to interact with Ets family proteins and a nuclear receptor COUP-TFII to regulate expression of genes involved in lymphangiogenesis. We have also identified novel Prox1 target genes, including FoxC2, Ang-2, and HoxD8.
|
-
[Journal Article] Ets family members induce lymphangiogenesis via physical and functional interaction with Prox12011
Author(s)
Yoshimatsu Y, Mihira H, Itoh T, Yuki K, Harada K, Morikawa M, Yamazaki T, Iwata C, Minami T, Morishita Y, Kodama T, Miyazono K, Watabe T
-
Journal Title
Peer Reviewed
-
-
[Journal Article] LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.2010
Author(s)
Sumida H, Noguchi K, Kihara Y, Abe M, Yanagida K, Hamano F, Sato S, Tamaki K, Morishita Y, Kano MR, Iwata C, Miyazono K, Sakimura K, Shimizu T, Ishii S.
-
Journal Title
Blood. 116(23)
Pages: 5060-5070
Peer Reviewed
-
-
[Journal Article] Identification of Prox1 targets during in vitro vascular differentiation from embryonic stem cells : functional roles of HoxD8 in lymphangiogenesis.2009
Author(s)
Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K
-
Journal Title
J Cell Sci. 122(21)
Pages: 3923-3930
Peer Reviewed
-
-
-
-
[Journal Article] Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.2007
Author(s)
Iwata C, Kano MR, Komuro A, Oka M, Kiyono K, Johansson E, Morishita Y, Yashiro M, Hirakawa K, Kaminishi M, Miyazono K
-
Journal Title
Cancer Res. 67(21)
Pages: 10181-10189
Peer Reviewed
-
-
-
-
-
-
-
-
-
