A birth cohort study to detect adverse health effects of environmental chemicals on the next generation and gene-environment interaction

2009 Fiscal Year Final Research Report

• Project/Area Number: 19209024
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Hokkaido University
• Principal Investigator: KISHI Reiko Hokkaido University, 大学院・医学研究科, 教授 (80112449)
• Co-Investigator(Kenkyū-buntansha): SATA Fumihiro 保健医療科学院, 疫学部社会疫学室, 室長 (90187154) ; YOSHIOKA Eiji 北海道大学, 大学院・医学研究科, 助教 (70435957) ; BAN Susumu 鈴鹿医療科学大学, 薬学部, 助手 (30399828) ; NAKAJIMA Sonomi 札幌医科大学, 保健医療学部, 講師 (70325877) ; SASAKI Seiko 北海道大学, 大学院・医学研究科, 助教 (30448831) ; MUROHASHI Harumitsu 北海道大学, 教育学研究院, 教授 (00182147) ; KAMIO Youko 国立精神・神経センター, 児童・思春期精神保健部, 研究部長 (00252445) ; SENGOKU Ysuhito 札幌医科大学, 保健医療学部, 教授 (10248669) ; HANAOKA Tomoyuki 昭和大学, 医学部, 非常勤講師 (00228503) ; SAIJO Yasuaki 旭川医科大学, 医学部, 教授 (70360906) ; FUJITA Shoichi 北海道大学, (連合)獣医学研究科, 教授 (10143314) ; NAKANAWA Hiroyuki 星薬科大学, 薬学部, 教授 (50150173) ; KAJIWARA Junboku 福岡県保健環境研究所, 保健科学部・生活科学課, 専門研究員 (80446848) ; YUASA Motoyuki 北海道大学, 大学院・医学研究科, 助教 (30463748)
• Co-Investigator(Renkei-kenkyūsha): ISHIZUKA Mayumi 北海道大学, 大学院・獣医学研究科 (50332474)
• Project Period (FY): 2007 – 2009
• Keywords: 母子保健 / 環境化学物質 / 次世代影響 / リスク評価 / 神経発達 / 遺伝環境交互作用 / 出生体重 / 出生コホート

Research Abstract

The prospective birth cohort with one obstetric hospital in Sapporo City has been conducted to investigate the association between child growth, neuro-development, and allergy, and low-level exposure to environmental chemicals during pregnancy, infancy and up to school age. A follow-up questionnaire was used at 18, 42, and 84 months of age to obtain relevant information including allergy prevalence, dietary habits, and smoking history of mother and the partner. The levels of PCDDs/PCDFs and PCBs in maternal blood and breast milk were measured using a high-resolution gas chromatography/high-resolution mass spectrometer (HRGC/HRMS). PFOS and PFOA levels in maternal blood were analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). We assessed the influence of low level intrauterine exposure of toxic chemicals on childhood neurodevelopment at 6, 18 and 42 months of age using the Bayley Scales of Infant Development second edition (BSID-II) and Japanese version of the Kaufman Assessment Battery for Children (K-ABC). The Japanese version of the Child Behavior Checklist (CBCL) was used to collect information on child behavior at age 43 months.

Research Products

• [Journal Article] 環境リスクによる潜在的な健康障害の解明特に次世代影響に関する研究 (2010)
  • Author(s): 岸玲子
  • Journal Title: 日本医師会雑誌 138 (10別冊) Pages: 56-59
• [Journal Article] Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milk (2010)
  • Author(s): Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Yasutake D, Onozuka D, Sasaki S, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T, Furue M.
  • Journal Title: Chemosphere 78 (2) Pages: 185-192
  • Peer Reviewed
• [Journal Article] Estrogen concentrations in beef and human hormone-dependent cancers (2009)
  • Author(s): Handa Y, Fujita H, Honma S, Minakami H, Kishi R.
  • Journal Title: Ann Oncol 20(9) Pages: 1610-1611
  • Peer Reviewed
• [Journal Article] Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight (2009)
  • Author(s): Konishi K, Sasaki S, Kato S, Ban S, Washino N, Kajiwara J, Todaka T, Hirakawa H, Hori T, Yasutake D, Kishi R.
  • Journal Title: Environ Res 109(7) Pages: 906-913
  • Peer Reviewed
• [Journal Article] Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population (2009)
  • Author(s): Sata F, Toya S, Yamada H, Suzuki K, Saijo Y, Yamazaki A, Minakami H, Kishi R.
  • Journal Title: Mol Hum Reprod 15(2) Pages: 121-130
  • Peer Reviewed
• [Journal Article] Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth (2009)
  • Author(s): Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R.
  • Journal Title: Environ Health Perspect 117(4) Pages: 660-667
  • Peer Reviewed
• [Journal Article] 環境と子どもの健康に関するコーホート研究の現状と課題遺伝的感受性素因の重要性 母の喫煙が子どもの胎内発育に及ぼす影響 (2009)
  • Author(s): 佐々木成子, 岸玲子
  • Journal Title: 日本衛生学雑誌 64(4) Pages: 759-764
  • Peer Reviewed
• [Journal Article] 環境と子どもの健康に関するコーホート研究の現状と課題環境と子どもの健康に関するコーホート研究について 子どもの発達評価とその課題 (2009)
  • Author(s): 中島そのみ, 岸玲子
  • Journal Title: 日本衛生学雑誌 64(4) Pages: 765-773
  • Peer Reviewed
• [Journal Article] 乳汁中ペルフルオロ化合物の定量及び母体血からの移行性 (2009)
  • Author(s): 中田彩子, 斉藤貢一, 岩崎雄介, 伊藤里恵, 岸玲子, 中澤裕之
  • Journal Title: 分析化学 58(8) Pages: 653-659
  • Peer Reviewed
• [Journal Article] Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation (2008)
  • Author(s): Kishi R, Sata F, Yoshioka E, Ban S, Sasaki S, Konishi K, Washino N.
  • Journal Title: Basic Clin Pharmacol Toxicol. 102(2) Pages: 191-203
  • Peer Reviewed
• [Journal Article] Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1 (2008)
  • Author(s): Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R.
  • Journal Title: American Journal of Epidemiology 167(6) Pages: 719-726
  • Peer Reviewed
• [Journal Article] Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan (2008)
  • Author(s): Todaka T, Hori T, Hirakawa H, Kajiwara J, Yasutake D, Onozuka D, Kato S, Sasaki S, Nakajima S, Saijo Y, Sata F, Kishi R, Iida T, Furue M.
  • Journal Title: Chemosphere 73(6) Pages: 923-931
  • Peer Reviewed
• [Journal Article] Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan (2008)
  • Author(s): Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Onozuka D, Kato S, Sasaki S, Nakajima S, Saijo Y, Sata F, Kishi R, Iida T, Furue M.
  • Journal Title: Chemosphere 72(8) Pages: 1152-1158
  • Peer Reviewed
• [Journal Article] Using microarray analysis to evaluate genetic polymorphisms involved in the metabolism of environmental chemicals (2007)
  • Author(s): Ban S., Kondo T., Ishizuka M., Sasaki S., Konishi K., Washino N., Fujita S., Kishi R.
  • Journal Title: Fukuoka Acta Medica 98(5) Pages: 208-214
  • Peer Reviewed
• [Journal Article] The Hokkaido Study on Environment and Children's Health in japan
  • Author(s): Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F. Cohort Profile
  • Journal Title: Int J Epidemiol (in press)
  • Peer Reviewed
• [Journal Article] Genetic Polymorphisms of 17 beta-Hydroxysteroid Dehydrogenase 3 and the Risk of Hypospadias
  • Author(s): Sata F, Kurahashi N, Ban S, Moriya K, Tanaka K. D., Ishizuka M, Nakao H, Yahata Y, Imai H, Kakizaki H, Nonomura K, Kishi R.
  • Journal Title: J Sex Med (in press)
  • Peer Reviewed
• [Journal Article] 生後6ケ月児に対するベイリー乳幼児発達検査-第2版による発達評価とその有用性
  • Author(s): 中島そのみ, 仙石泰仁, 中村裕二, 加藤静恵, 岸玲子
  • Journal Title: 作業療法 (in press)
  • Peer Reviewed
• [Presentation] Effects of maternal smoking and 5, 10-MTHFR C677T Polymorphism on infant's birthweight -The impact of folic acid supplementation- (2009)
  • Author(s): Yila TA, Sasaki S, Braimoh TS, Kobayashi S, Limpar M, Yoshioka E, Kishi R.
  • Organizer: 3rd Annual Conference on Genomics of Common Diseases September 23-26
  • Place of Presentation: Cambridge, UK
  • Year and Date: 20090923-20090926
• [Presentation] Prenatal Exposure to Dioxins in Relation to IgE level of Newborn and Allergic and Infectious Diseases of Infants-Hokkaido Study on Environment and Children's Health-3rd WHO International Conference on CEH (2009)
  • Author(s): Kishi R, Washino N, Miyashita C, Sasaki S, Yuasa M, Yoshioka E, Konishi K, Kajiwara J, Todaka T, Hirakawa H, Hori T.
  • Place of Presentation: Bexco, Busan, Korea
  • Year and Date: 20090607-20090610
• [Presentation] Effect of Maternal Serum Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on Maternal and Newborn's Thyroid Hormone-Hokkaido Study on Environment and Children's Health- (2009)
  • Author(s): Yoshioka E, Yuasa M, Katoh S, Sasaki S, Washino N, Kanazawa A, Konishi K, Kishi R, Nakata A, Iwasaki Y, Ito R, Saito K, Nakazawa H.
  • Organizer: rd WHO International Conference on CEH
  • Place of Presentation: Bexco, Busan, Korea
  • Year and Date: 20090607-20090610
• [Presentation] 胎児発育に及ぼす母の喫煙の影響とNQO1およびMGMT遺伝子多型との関連-『環境と子供の健康に関する北海道スタディ』- (2009)
  • Author(s): 佐々木成子, 坂晋, 湯浅資之, 吉岡英冶, 金澤文子, 鷲野考揚, 小西香苗, 宮下ちひろ, 小林澄貴, 岡田恵美子, 佐多文宏, 近藤朋子, 岸玲子
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市 金沢市民文化ホール
  • Year and Date: 20090123-20090124
• [Presentation] 胎児発育に影響を与えるダイオキシン類の暴露と遺伝要因との関連--「環境と子供の健康 北海道スタディ」-- (2009)
  • Author(s): 小林澄貴, 佐々木成子, 坂晋, 近藤朋子, 湯浅資之, 吉岡英治, 金沢文子, 鷲野考揚, 小西香苗, 梶原淳睦, 戸高尊, 平川博仙, 堀就英, 安武大輔, 岸玲子
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市 金沢市民文化ホール
  • Year and Date: 20090123-20090124
• [Presentation] 有機フッ素化合物の妊娠中暴露による次世代影響-「環境と子どもの健康 : 北海道スタディ」から- (2009)
  • Author(s): 岸玲子
  • Organizer: 環境ホルモン学会シンポジウム
  • Place of Presentation: 東京大学, 東京
  • Year and Date: 2009-12-07
• [Presentation] 胎児期ダイオキシン類曝露が出生体重に与える影響-喫煙の交互作用 環境と子どもの健康に関する北海道スタディー (1) (2009)
  • Author(s): 小西香苗, 佐々木成子, 鷲野考揚, 宮下ちひろ, 岡田恵美子, 吉岡英治, 湯浅資之, 梶原淳睦, 戸高尊, 岸玲子
  • Organizer: 第79回日本衛生学会学術総会 第79回日本衛生学会学術総会
  • Place of Presentation: 東京都 北里大学
  • Year and Date: 2009-03-30
• [Presentation] 胎児期のダイオキシン類曝露と乳幼児期アレルギー症状および感染症との関連の検討-環境と子供の健-北海道スタディ (2)- (2009)
  • Author(s): 宮下ちひろ, 佐々木成子, 鷲野考揚, 小西香苗, 岡田恵美子, 吉岡英治, 湯浅資之, 梶原淳睦, 戸高尊, 岸玲子
  • Organizer: 第79回日本衛生会学術総会
  • Place of Presentation: 東京都 北里大学
  • Year and Date: 2009-03-30
• [Presentation] 胎児期の有機フッ素化合物曝露と乳幼児期のアレルギー症状との関連の検討-環境と子どもの健康に関する北海道スタディ (3)- (2009)
  • Author(s): 岡田恵美子, 鷲野考揚, 佐々木成子, 小西香苗, 宮下ちひろ, 吉岡英治, 湯浅資之, 伊藤里恵, 中澤裕之, 岸玲子
  • Organizer: 第79回日本衛生学会学術総会
  • Place of Presentation: 東京都 北里大学
  • Year and Date: 2009-03-30
• [Presentation] Effect of Prenatal Exposure to Dioxins on Size for Ges tational Age. International Society for Environmental Epidemiology & Int ernational Society of Exposure Analy sis 2008 Joint Annual Conference (2008)
  • Author(s): Konishi K, Sasaki S, Kato S, Ban S, Washino N, Yuasa M, Yoshioka E, Kajiwara J, Todaka T, Hirakawa H, Hori T, Yasutake D, Yasutake A, Hachiya N, Kishi R.
  • Organizer: Pasadena Convention Center
  • Place of Presentation: Pasadena, CA, U.S.A
  • Year and Date: 20081012-20081016
• [Presentation] The review of epidemiological studies on gestational and parenting factors for ADHD symptoms in preschoolers (2008)
  • Author(s): Otake Y, Yuasa M, Yoshioka E, Kishi R, Nakajima S.
  • Organizer: 11th International Congress of Behavioral Medicine
  • Place of Presentation: Rissho University, Tokyo, Japan
  • Year and Date: 20080827-20080830
• [Presentation] 医療用アルブミン製剤および各種アルブミン試薬から検出されるパーフルオロ化合物濃度の比較検討 (2008)
  • Author(s): 手塚浩子, 斉藤貢一, 中田彩子, 坂田脩, 岩崎雄介, 伊藤里恵, 和泉俊一郎, 牧野恒久, 岸玲子, 中澤裕之
  • Organizer: 第69回分析化学討論会
  • Place of Presentation: 愛知県 (名古屋国際会議場)
  • Year and Date: 20080515-20080516
• [Presentation] The Hokkaido study on environment and children's health-Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals. (2008)
  • Author(s): Kishi R.
  • Organizer: ISEE and the 3rd Scientific Conference of Regional Forum of Environment and Health in Asia
  • Place of Presentation: Lotte Hotel, Jeju, Korea
  • Year and Date: 20080417-20080419
• [Presentation] Correlatns amongio Serum PCB/Dioxins Levels, Smoking Status, and gene Polymorphisms in Mothers from Hokkaido, Japan. (2007)
  • Author(s): Ban S.
  • Organizer: 27th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: Hotel Okura Tokyo, Tokyo, Japan
  • Year and Date: 20070902-20070907
• [Presentation] Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation (2007)
  • Author(s): Kishi R.
  • Organizer: Prenatal Programming and Toxicity 2007
  • Place of Presentation: The Nordic Culture Center, Torshavn, Faroe Islands
  • Year and Date: 20070520-20070524
• [Remarks] ホームページ等 研究内容:
  • URL: http://www.med.hokudai.ac.jp/~pubmed-w/kenkyu/index.htm
• [Remarks] 研究成果:
  • URL: http://www.med.hokudai.ac.jp/~pubmed-w/gyouseki/index.htm