2009 Fiscal Year Final Research Report
Basic and clinical research for evaluating micro-environmental changes in sentinel lymph node produced by micro-metastasis of carcinoma cell.
| Project/Area Number |
19209044
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
OHHASHI Toshio Shinshu University, 医学部, 教授 (80020832)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Yoshiko 信州大学, 医学部, 准教授 (10362112)
NAGAI Takashi 信州大学, 医学部, 助教 (50514353)
IKOMI Fumitaka 信州大学, 医学部, 准教授 (50262704)
MIZUNO Risuke 信州大学, 医学部, 講師 (30273080)
HOSAKA Kayoko 信州大学, 医学部, 助教 (30362122)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 癌転移 / センチネルリンパ節 / 分子プロファイリング / 癌抗原 / 生体顕微鏡観察 |
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| Research Abstract |
(1) We reported in AJP (Cell Physiology, 295 : C1123-C1132, 2008) that human breast cancer cell line, MDA-MB-231 has produced ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human endothelial cells.
(2) We reported in Cancer Science (100 : 419-428, 2009) that chemokine CCL2 has facilitated ICAM-1-mediated interactions of Cancer Cells to human lymphatic endothelial cells.
(3) We reported in AJP (Cell Physiology, 298 : C647-C655, 2010) that shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells.
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