Surveillance of African trypanosomiases in domestic animals and wildlife

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19255015
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: SUGIMOTO Chihiro Hokkaido University, 人獣共通感染症リサーチセンター, 教授 (90231373)
• Project Period (FY): 2007 – 2010
• Keywords: アフリカ / トリパノソーマ / ツェツェバエ / 病原性 / ゲノム

Research Abstract

本研究では新興人獣共通感染症としてトリパノソーマ原虫症について東・南部アフリカでの実態を把握、その病原性進化の過程を追跡することを目的としている。アフリカ諸国の研究者との研究ネットワークを活用して家畜・野生動物ならびに人における感染の実態を共同で調査し、原虫進化の道筋を辿ると同時に、感染巣の拡大が起きているか原発地域の周辺地城での原虫の分子疫学的モニタリングを行い、予防対策確立に必要な情報を発生各国に提供する。さらに、ツェツェバエの各種生物学的性状をゲノム、cDNA解析から明らかにして、ベクターコントロール法の開発を行い、HAT予防対策確立においてブレークスルーを図ることを研究の目的とする

Research Products

• [Journal Article] A field study to estimate the prevalence of bovine African Trypanosomosis in Butaleja District, Uganda (2009)
  • Author(s): Jing Z, Magona JW, Sakurai T, Thekisoe OM, Otim CP, Sugimoto C, Inoue N.
  • Journal Title: J Vet Med Sci. 71(4) Pages: 525-527
• [Journal Article] Stability of Loop-Mediated Isothermal Amplification (LAMP) reagents and its amplification efficiency on crude trypanosome DNA templates (2009)
  • Author(s): Thekisoe OM, Bazie RS, Coronel-Servian AM, Sugimoto C, Kawazu S, Inoue N.
  • Journal Title: J Vet Med Sci. 71(4) Pages: 471-475
• [Journal Article] Preliminary studies on the effects of orally-administered Transforming Growth Factor-beta on protozoan diseases in mice (2009)
  • Author(s): Namangala B Inoue N. Sugimoto C.
  • Journal Title: Jpn J Vet Res. 57(2) Pages: 101-108
• [Journal Article] Effect of CD4(+)CD25(+) T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosome congolense (2008)
  • Author(s): Namangala B, Yokoyama N, Ikehara Y, Taguchi O, Tsujimura K, Sugimoto C, Inoue N.
  • Journal Title: J Vet Med Sci. 70(8) Pages: 751-759
• [Journal Article] Prevalence of Theileria equi and Babesia caballi infections in horses belonging to resource-poor farmers in the north-eastern Free State Province, South Africa (2008)
  • Author(s): Motloang MY, Thekisoe OM, Alhassan A, Bakheit M, Motheo MP, Masangane FE, Thibedi ML, Inoue N, Igarashi I, Sugimoto C, Mbati PA.
  • Journal Title: Onderstepoort J Vet Res. 75(2) Pages: 141-146
• [Presentation] invited lecture "Development of loop-mediated isothermal amplification (LAMP) for diagnoses of trypanosomoses" (2009)
  • Author(s): Chihiro Sugimoto
  • Organizer: 45th Annual Meeting of Malaysian Society of Parasitology and Tropical Medicine
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 20090300
• [Book] Theileria(Eds. V. Nene and C. Kole., Genome Mapping and Genomics in Animal-Associated Microbes.) (2009)
  • Author(s): Richard P. Bishop, David O. Odongo, David J. Mann, Terry W. Pearson, Chihiro Sugimoto, Lee R. Haines Elizabeth Glass, Kirsty Jensen, Ulrike Seitzer, Jabbar S. Ahmed, Simon P. Graham, Etienne P de Villiers
  • Total Pages: 191-231
  • Publisher: Springer-Verlag
• [Remarks] ツェツェバエ完全長cDNAデータバンク公開
  • URL: http://fullmal.ims.u-tokyo.ac.jp/