2009 Fiscal Year Final Research Report
Study of the establishment and function of the habenulo-interpeduncular tract
| Project/Area Number |
19300115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OKAMOTO Hitoshi The Institute of Physical and Chemical Research, 発生遺伝子制御研究チーム, シニア・チームリーダー (40183769)
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| Co-Investigator(Kenkyū-buntansha) |
AIZAWA Hidenori 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 副チームリーダー (80391837)
AOKI Tazu 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 (10425605)
AGETSUMA Masakazu 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 (30425607)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 発生 / 発達 / 再生神経科学 |
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| Research Abstract |
The habenula is a part of the neural circuit connecting the telencephalic limbic system with the monoaminergic neurons in the brain stem. Taking advantage of the high degree of evolutionary conservation of this neural circuit from fish to human, we have carried out genetic manipulation to inactivate specific subnuclei of the habenula in zebrafish and obtained a clue suggesting that the habenula plays an important role for experience-dependent decision in response to fear by animals.
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