2009 Fiscal Year Final Research Report
Plastic changes associated with spontaneous motor activity at neuromuscular junction.
| Project/Area Number |
19300140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Gunma University |
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Principal Investigator |
KUROMI Hiroshi Gunma University, 薬学部, 教授 (30009633)
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| Co-Investigator(Kenkyū-buntansha) |
KIDOKORO Yoshiaki 東北大学, 大学院・生命科学研究所, 客員教授 (00053083)
UENO Kouhei 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 (40332556)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ニューロン・シナプス機能 |
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| Research Abstract |
The present study revealed that (1) there were multiple Ca^<2+> channels at motor nerve terminals of Drosophila larvae. (2) After exocytosis of synaptic vesicles at nerve terminals, endocytosis, the first step of vesicle recycling, occurred at active zone and non-active zone linked to each specific CaCa^<2+> channels. (3) Both endocytosis contribute coordinately to maintain synaptic transmission, depending on degree of motor nerve activity. (4) In addition, changes in tubulin states, monomer or dimmer and their distribution, were associated with dynamics of synaptic vesicles. These results suggest that changes in synaptic vesicle traffic underlines plastic changes in synaptic transmission after strong activity of motor nerve.
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