2010 Fiscal Year Final Research Report
Development of Chemical Release Controlling Devices for Differentiation Induction of Neural Stem Cells
| Project/Area Number |
19300161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu Institute of Technology |
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Principal Investigator |
YASUDA Takashi Kyushu Institute of Technology, 大学院・生命体工学研究科, 准教授 (80270883)
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| Project Period (FY) |
2007 – 2010
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| Keywords | マイクロ流体デバイス / マイクロ流路 / 微小孔 / マイクロバルブ / 神経幹細胞 / 細胞刺激 / 分化誘導 |
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| Research Abstract |
Techniques of chemical release control for differentiation induction of neural stem cells were developed. First, four nanohole arrays and microvalves were fabricated at the bottom of a cell-culturing chamber, and chemical release from the nanoholes was controlled by switching open/close of the microvalves. Next, a sheathflow was generated in a microchannel under a chamber, and chemical release from microholes was controlled by regulating flow rates of three fluids which form the sheathflow. Moreover, in order to permit multiple chemicals to be released on a single device, 64 chambers were arranged in an 8 x 8 matrix, and each of 8 microchannels was located directly under a row of chambers.
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