Development of the fluorescence imaging system for medical applications based on the ultrasonic tagging technique

2009 Fiscal Year Final Research Report

• Project/Area Number: 19300162
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku Institute of Technology
• Principal Investigator: KOBAYASHI Masaki Tohoku Institute of Technology, 工学部, 教授 (90332981)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Motohiro 東北大学, 大学院・医学系研究科, 准教授 (10333808) ; ENOMOTO Masaru 東北工業大学, 工学部, 教授 (10085392)
• Project Period (FY): 2007 – 2009
• Keywords: 蛍光 / 超音波 / 音響光学効果 / 診断装置 / 医用画像 / センチネルリンパ節

Research Abstract

Non-invasive imaging technique of fluorescent marker in living body for diagnosis of physiological and pathological condition has been studied. Ultrasonic tagging technique based on the acousto-optic effect has been examined and the tomographic imaging system to determine the localized fluorescent substances at the depth of 30mm has been developed.

Research Products

• [Journal Article] Nano-imaging of the lymph network structure with quantum dots (2010)
  • Author(s): M. Hikage, K. Gonda, M. Takeda, T. Kamei, M. Kobayashi, M. Kumasaka, M. Watanabe, S. Satomi, N. Ohuchi
  • Journal Title: Nanotechnology Vol.21 Pages: 185103
  • Peer Reviewed
• [Journal Article] Imaging of Ultraweak Spontaneous Photon Emission from Human Body Displaying Diurnal Rhythm (2009)
  • Author(s): M. Kobayashi, D. Kikuchi, H. Okamura
  • Journal Title: PLoS ONE Vol.4 Pages: e6256
  • Peer Reviewed
• [Journal Article] 超音波変調による生体蛍光イメージング (2009)
  • Author(s): 小林正樹
  • Journal Title: 光学 Vol.38 Pages: 316-321
• [Journal Article] In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine (2008)
  • Author(s): M. Takeda, H. Tada, H. Higuchi, Y. Kobayashi, M. Kobayashi, Y. Sakurai, T. Ishida, N. Ohuchi
  • Journal Title: Breast Cancer Vol.15 Pages: 145-152
  • Peer Reviewed
• [Journal Article] 小林正樹 (2008)
  • Author(s): 生命科学・医学応用のための極微弱発光・蛍光イメージング技術
  • Journal Title: 顕微鏡 Vol.43 Pages: 202-206
• [Journal Article] Fluorescence tomography of biological tissue based on ultrasound tagging technique, M. Kobayashi (2007)
  • Author(s): M. Kobayashi, T. Mizumoto, T.Q. Duc, M. Takeda
  • Journal Title: Proc. SPIE 6633 Pages: 663306-1-5
• [Journal Article] J. Kim, Y. Kim, Y.J. Lee, M. Kobayashi, Y. Tsutsumi, R. Kondo, S.K. Lee, K.S. Soh (2007)
  • Author(s): Spontaneous ultraweak photon emission during the growth of the cell population of cultured HeLa cell line
  • Journal Title: J. Health Sci Vol.53 Pages: 481-485
  • Peer Reviewed
• [Journal Article] M. Kobayashi, K. Sasaki, M. Enomoto, Y. Ehara (2007)
  • Author(s): Highly sensitive determination of transient generation of biophotons during hypersensitive response to cucumber mosaic virus in cowpea
  • Journal Title: J. Exp. Botany Vol.58 Pages: 465-472
  • Peer Reviewed
• [Presentation] Basic examination of the endoscopic surgery using nanoparticle tracer (2009)
  • Author(s): M. Hikage, M. Takeda, T. Kamei, M. Kobayashi, K. Gonda, M. Kumasaka, T. Nakano, Y. Sakurai, M. Kawai, C. Li-man, Y. Hamanaka, Y. Hamada, S. Satomi, N. Ohuchi
  • Organizer: 2nd International Symposium on Nanomedicine 2009
  • Place of Presentation: Okazaki, Japan
  • Year and Date: 2009-02-06
• [Presentation] Fluorescence tomography based-on acousto-optic modulations with phased-array ultrasound transducer (2009)
  • Author(s): Q.D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M. Kobayashi
  • Organizer: BiOS Part of SPIE Photonic West
  • Place of Presentation: San Jose, USA
  • Year and Date: 2009-01-27
• [Presentation] Basic study on application of the phased-array transducer to determine fluorescence in turbid media based-on acousto-optic effects (2008)
  • Author(s): Q.D. Trinh, Y. Nanbu, T. Suzuki, S. Takahashi, M. Takeda, M. Kobayashi
  • Organizer: nternational Conference on Laser Applications in Life Sciences (LALS 2008)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-12-04
• [Presentation] Basic examination of the fluorescent endoscopic surgery using nanoparticle tracer (2008)
  • Author(s): M. Hikage, M. Takeda, T. Kamei, M. Kobayashi, K. Gonda, M. Kumasaka, T. Nakano, Y. Sakurai, M. Kawai, C. Li-man, Y. Hamanaka, Y. Hamada, S. Satomi, N. Ohuchi
  • Organizer: 11th World Congress of Endoscopic Surgery
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2008-09-05
• [Presentation] ナノ蛍光微粒子によるセンチネルリンパ節検索のための腹腔内視鏡蛍光イメージングシステムの開発 (2008)
  • Author(s): 熊坂増高, 日景允, 亀井尚, 武田元博, 大内憲明, 小林正樹
  • Organizer: 平成20年度電気関係学会東北支部連合大会
  • Place of Presentation: 郡山
  • Year and Date: 2008-08-22
• [Presentation] 超音波タグ蛍光断層イメージング法による生体組織の蛍光断層画像計測 (2008)
  • Author(s): 南部雄也, 鈴木知佳, 高橋誠樹, Trinh Quang Duc, 小林正樹
  • Organizer: 平成20年度電気関係学会東北支部連合大会
  • Place of Presentation: 郡山
  • Year and Date: 2008-08-22
• [Presentation] 機能性ナノ粒子によるナノからマクロレベルの生体イメージング (2008)
  • Author(s): 武田元博, 樋口秀男, 小林正樹, 小林芳男, 大内憲明
  • Organizer: 第55回応用物理学関係連合講演会
  • Place of Presentation: 日本大学・船橋
  • Year and Date: 2008-03-29
• [Presentation] Tomographic Imaging of Fluorophore Embedded in Biological Tissue Based on Ultrasound Tagging Technique (2007)
  • Author(s): Q.D. Trinh, T. Mizumoto, Y. Nanbu, M. Takeda, M. Kobayashi
  • Organizer: The 7th pacific Rim Conference on Lasers and Electro-Optics (CLEO)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-08-30
• [Presentation] Fluorescence Tomography of Biological Tissue Based on Ultrasound Tagging Technique (2007)
  • Author(s): M. Kobayashi, T. Mizumoto, T.Q. Duc, M. Takeda
  • Organizer: Europian conferences on Biomedical Optics/ in 18th International Congress on Photonics in Europe
  • Place of Presentation: Munich, Germany
  • Year and Date: 2007-06-18
• [Presentation] 音響光学効果を利用した超音波タグ生体蛍光断層イメージングI (2007)
  • Author(s): 水本喬, Trinh Quang Duc, 武田元博, 小林正樹
  • Organizer: 第54回応用物理学関係連合講演会講演予稿集
  • Place of Presentation: 青山学院大学・相模原
  • Year and Date: 2007-03-28
• [Book] 機能性ナノ粒子による生体イメージング-がん診療への応用-. ナノメディシンナノテクの医療応用(宇理須恒雄) (2008)
  • Author(s): 武田元博,小林芳男,小林正樹,桜井遊,甘利正和,石田孝宣,鈴木昭彦,大内憲明
  • Publisher: オーム社
• [Book] 量子ドットを用いた生体機能非侵襲計測のための蛍光画像計測技術の開発. 量子ドットの生命科学領域への応用(山本重夫監) (2007)
  • Author(s): 小林正樹
  • Total Pages: 231-239
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.tohtech.ac.jp/~elecs/ca/kobayashilab_hp/index.html
• [Patent(Industrial Property Rights)] 蛍光断層画像計測装置 (2010)
  • Inventor(s): 小林正樹
  • Industrial Property Rights Holder: 小林正樹,(株)システム計測
  • Industrial Property Number: 特許特許第4518549
  • Filing Date: 2010-05-28