2010 Fiscal Year Final Research Report
Modulation of cellular metabolism based on controlling the mobility of multivalent ligands using stimuli-responsive polyrotaxanes
| Project/Area Number |
19300170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
YUI Nobuhiko Japan Advanced Institute of Science and Technology, 生体材料工学研究所, 教授 (70182665)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 細胞工学 / 生体機能材料 / リガンド導入ポリロタキサン / 多価相互作用 |
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| Research Abstract |
In order to aim at controlling cellular response via stimuli-responsive polyrotaxanes, the preparation of a variety of polyrotaxanes, the characterization of their properties, and the protein and cellular responses to these polyrotaxanes were performed. Macromolecular inclusion of loose-fit polyrotaxane, temperature-responsive polyrotaxane formation, enhanced binding of mannose-conjugated polyrotaxane with specific protein, and the production of anti-inflammatory cytokine from macrophages were clarified in this study.
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