2009 Fiscal Year Final Research Report
Development of siRNA delivery system by the combination of bubble liposomes and ultrasound
| Project/Area Number |
19300185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Teikyo University |
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Principal Investigator |
MARUYAMA Kazuo Teikyo University, 薬学部, 教授 (30130040)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Ryo 帝京大学, 薬学部, 助教 (90384784)
TAKIZAWA Tomoko 帝京大学, 薬学部, 助手 (90260934)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 低侵襲治療システム |
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| Research Abstract |
The preparation method (GMP, controlled size) of bauble liposome was established. The effectiveness of siRNA in vitro and in vivo was observed. However, its effect was not enough for treatment. The condition of ultrasound and bubble liposome amount, etc, should be considered. Mouse bladder cancer therapy by the siRNA for PLK-1 is undergoing.
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[Journal Article] Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles.2008
Author(s)
Ryo Suzuki, Tomoko Takizawa, Yoichi Negishi, Kosuke Hagisawa, Naoki Utoguchi, Kaori Sawamura, Kumiko Tanaka, Eisuke Namai, Yusuke Oda, Toshihiko Nishioka, Yasuhiro Matsumura, Kazuo Maruyama
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Journal Title
J. Control. Release 125
Pages: 137-144
Peer Reviewed
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