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2009 Fiscal Year Final Research Report

Morphology Formation Dynamics of Multi-Component Vesicles

Research Project

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Project/Area Number 19340118
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics/Chemical physics
Research InstitutionOchanomizu University

Principal Investigator

IMAI Masayuki  Ochanomizu University, 大学院・人間文化創成科学研究科, 教授 (60251485)

Co-Investigator(Kenkyū-buntansha) URAKAMI Naohito  山口大学, 理工学研究科, 講師 (50314795)
NAKAYA Kaori  お茶の水女子大学, 大学院・人間文化創成科学研究科, 助教 (50323861)
Project Period (FY) 2007 – 2009
Keywords多成分ベシクル / 生体膜 / 膜内相分離 / 自発曲率 / 膜接着 / 孔形成
Research Abstract

我々は生体膜の示す様々な膜変形現象を、多成分ベシクルを用いたモデルを通して研究した。様々な形状を持つベシクルで相分離を起こすことにより、ベシクルが内側に分裂したり、外側に分裂したりする現象、球状のベシクルが数珠状に繋がる現象等、相分離するベシクルに特徴的な変形を示す事がわかった。さらに、脂質分子の自発曲率と相分離を結合させることにより接着や孔形成などの機能性膜変形も再現できる事がわかった。

  • Research Products

    (20 results)

All 2010 2009 2008 2007 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (8 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Nano-meter-sized domain formation in lipid membranes observed by small angle neutron scattering2008

    • Author(s)
      T. Masui, N. Urakami, M. Imai
    • Journal Title

      Eur. Phys. J. E 27

      Pages: 379-389

    • Peer Reviewed
  • [Journal Article] Shape Deformation of Vesicle Coupled with Phase Separation M. Yanagisawa2008

    • Author(s)
      M. Imai, T. TaniguchiProgress
    • Journal Title

      of Theoretical Physics Supplement 175

      Pages: 71-80

    • Peer Reviewed
  • [Journal Article] Adhesion of Binary Giant Vesicles Containing Negative Spontaneous Curvature Lipids Induced by Phase Separation2008

    • Author(s)
      Y. Sakuma, M. Imai, M. Yanagisawa, S. Komura
    • Journal Title

      Eur. Phys. J. E 25

      Pages: 403-413

    • Peer Reviewed
  • [Journal Article] Shape deformation of ternary vesicles coupled with phase separationM. Yanagisawa2008

    • Author(s)
      M. Imai, T. TaniguchiPhys
    • Journal Title

      Rev. Lett. 100

      Pages: 148102(1-4)

  • [Journal Article] Lamellar to Micelle Transition of Nonionic Surfactant Assemblies Induced by Addition of Colloidal Particles2008

    • Author(s)
      Y. Suganuma, N. Urakami, R. Mawatari, S. Komura, Kaori Nakaya-Yaegashi, M. Imai
    • Journal Title

      J. Chem. Phys 129

      Pages: 134903

    • Peer Reviewed
  • [Journal Article] り8) Concentration fluctuations in binary fluid membranes2007

    • Author(s)
      K. Seki, S. Komura, M. Imai
    • Journal Title

      J. Phys. 19(Condens. Matter)

      Pages: 072101

    • Peer Reviewed
  • [Journal Article] Growth Dynamics of Domains in Ternary Fluid Vesicles2007

    • Author(s)
      M. Yanagisawa, M. Imai, T. Masui, S. Komura, Takao Ohta
    • Journal Title

      Biophysical J 92

      Pages: 115-125

  • [Journal Article] Pore Formation in a Binary Giant Vesicle Induced by Cone-Shaped Lipids

    • Author(s)
      Y. Sakuma, T. Taniguchi, M. Imai
    • Journal Title

      Biophys. J. (in press)

    • Peer Reviewed
  • [Journal Article] Diffusion of domains on nanometer sized vesicle

    • Author(s)
      Y. Sakuma, N. Urakami, Y. Ogata, M. Nagao, S. Komura, T. Kawakatsu, M. Imai
    • Journal Title

      J. Phys. Conf. Ser. (in press)

    • Peer Reviewed
  • [Presentation] Diffusion of nanometer-sized domains on a vesicle Biophys. Soc.2010

    • Author(s)
      M. Imai
    • Organizer
      54th annual meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2010-02-22
  • [Presentation] 多成分ベシクルの変形挙動特定領域研究非平衡物理学の創成2009

    • Author(s)
      今井正幸
    • Organizer
      第3回公開シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-11-21
  • [Presentation] Inter-membrane interactions modulated by addition of guest components2009

    • Author(s)
      M. Imai
    • Organizer
      Conference on Neutron Scattering & Mesoscopic Systems
    • Place of Presentation
      Goa, India
    • Year and Date
      2009-10-12
  • [Presentation] Lamellar to Micelle Transition of Nonionic Surfactant Assemblies Induced by Confinement of Colloidal Particles.2009

    • Author(s)
      M. Imai
    • Place of Presentation
      Knoxville USA
    • Year and Date
      2009-05-05
  • [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation International symposium on non-equilibrium soft matter2008

    • Author(s)
      M. Imai
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-06-03
  • [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation International Workshopn on Physical Phenomena in Multi-Component Membranes2008

    • Author(s)
      M. Imai
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-18
  • [Presentation] Domain growth of deformed vesicles International Soft Matter Conference2007

    • Author(s)
      M. Imai
    • Place of Presentation
      Aachen, Germany
    • Year and Date
      2007-10-01
  • [Presentation] Shape Deformation of Vesicle Coupled with Phase Separation2007

    • Author(s)
      M. Imai
    • Organizer
      The 5th International workshop on complex systems
    • Place of Presentation
      Sendai
    • Year and Date
      2007-09-26
  • [Book] ソフトマターの秩序形成2007

    • Author(s)
      今井正幸
    • Total Pages
      399
    • Publisher
      シュプリンガー・ジャパン東京
  • [Remarks]

    • URL

      http://sofia.phys.ocha.ac.jp/imailab/index.html

  • [Patent(Industrial Property Rights)] 2成分ベシクルによるマイクロメートルサイズの物質輸送システム2009

    • Inventor(s)
      佐久間由香・今井正幸
    • Industrial Property Rights Holder
      お茶の水女子大学
    • Industrial Property Number
      特許・特願2009-42357
    • Filing Date
      2009-02-25

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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