2009 Fiscal Year Final Research Report
Stabilization mechanism of collagen helix by using host-guest model peptides
| Project/Area Number |
19350059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OKUYAMA Kenji Osaka University, 大学院・理学研究科, 教授 (30038020)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Fumitoshi 大阪大学, 大学院・理学研究科, 准教授 (70214468)
KAWAGUCHI Tatsuya 大阪大学, 大学院・理学研究科, 助教 (10314353)
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| Project Period (FY) |
2007 – 2009
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| Keywords | コラーゲン / 三重らせん / モデルペプチド / 高分解能解析 / 構造安定化 |
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| Research Abstract |
Understanding the mechanism of the stabilization and destabilization of a collagen helix induced by Hyp residues is one of important issues in structural study of collagen. The present study has revealed the rule for ring puckering of Hyp residues, which governs stabilization and destabilization of collagen helix, by the high resolution structure analyses of collagen-model peptides.
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[Journal Article] Comments on Microfibrillar structure of type I collagen in situ by Orgel, et al.2006
Author(s)
K. Okuyama, H.P. Bachinger, K. Mizuno, S. Boudko, J. Engel, R. Berisio, L. Vitagliano
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Journal Title
PNAS, Acta Cryst. 103,D65
Pages: 9001-9005, 1007-1008
Peer Reviewed
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