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2009 Fiscal Year Final Research Report

Molecular basis of pathogenicity of classical swine fever virus -Mechanism of down regulation of innate immunity in the cells and pigs infected with classical swine fever virus-

Research Project

  • PDF
Project/Area Number 19380170
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionHokkaido University

Principal Investigator

SAKODA Yoshihiro  Hokkaido University, 大学院・獣医学研究科, 准教授 (40333637)

Co-Investigator(Kenkyū-buntansha) AOKI Hiroshi  日本獣医生命科学大学, 獣医学部, 講師 (10440067)
Project Period (FY) 2007 – 2009
Keywords豚コレラウイルス / 病原性 / 自然免疫 / ペスチウイルス / 宿主
Research Abstract

To assess the molecular basis of classical swine fever virus, the mechanism of down regulation of innate immunity mediated by type-1 interferon was analyzed using mutant viruses constructed by reverse genetics. Critical amino acids of N^<pro> protein for the control of type-1 interferon production were determined and it was concluded that the down regulation of innate immunity mediated by type-1 interferon was one of the important factors for the pathogenicity of classical swine fever virus in pigs.

  • Research Products

    (11 results)

All 2010 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro2009

    • Author(s)
      Ruggli, N., Summerfield, A., Fiebach, A.R., Guzylack-Piriou, L., Bauhofer, O., Lamm, C.G., Waltersperger, S., Matsuno, K., Liu, L., Gerber, M., Choi, K.H., Hofmann, M.A., Sakoda, Y., Tratschin, J. D
    • Journal Title

      J. Virol 83

      Pages: 817-829

    • Peer Reviewed
  • [Journal Article] Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus2008

    • Author(s)
      Kameyama, K., Sakoda, Y., Matsuno, K., Ito, A., Tajima, M., Nakamura, S., Kida, H
    • Journal Title

      Microbiol. Immunol 52

      Pages: 277-282

    • Peer Reviewed
  • [Journal Article] Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation2007

    • Author(s)
      Bauhofer, O., Summerfield, A., Sakoda, Y., Tratschin, J.D., Hofmann, M.A., Ruggli, N
    • Journal Title

      J. Virol 81

      Pages: 3087-3096

    • Peer Reviewed
  • [Presentation] 豚コレラ弱毒生ワクチン株の豚扁桃継代による病原性の復帰2010

    • Author(s)
      吉野史、迫田義博、杉田征彦、野村拓志、山本直樹、岡松正敏、喜田宏
    • Organizer
      第149回日本獣医学会
    • Place of Presentation
      日本獣医生命科学大学、東京
    • Year and Date
      2010-03-26
  • [Presentation] 細胞病原性牛ウイルス性下痢ウイルスNose株に含まれる費細胞病原性準種の遺伝子構造解析2010

    • Author(s)
      青木博史
    • Organizer
      第149回日本獣医学会
    • Place of Presentation
      日本獣医生命科学大学、東京
    • Year and Date
      2010-03-26
  • [Presentation] 豚コレラウイルスの病原性の分子基盤-弱毒生ワクチン株の豚継代による病原性の部分復帰-2009

    • Author(s)
      迫田義博、岡松正敏、野村拓志、杉田征彦、吉野史、喜田宏
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      20091025-20091026
  • [Presentation] Induction of apoptosis in porcine kidney cells by type I interferon induced by infection with classical swine fever virus2008

    • Author(s)
      Sakoda Y, Ito A, Kameyama K, Nomura T, Ruggli N, Tratschin J. -D, Kida H
    • Organizer
      The 7th ESVV Pestivirus Symposium
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      20080916-20080919
  • [Presentation] Expression kinetics of Interferon Promoter Stimulator-1(IPS-1) inducing natural immunity in the cells infected with Classical Swine Fever Virus2008

    • Author(s)
      Nomura T, Sakoda Y, Matsuno K, Kida H
    • Organizer
      7th ESVV Pestivirus Symposium
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      20080916-20080919
  • [Presentation] 豚コレラウイルスのCPK-NS細胞に対する病原性の解析2007

    • Author(s)
      伊藤麻子、迫田義博、Nicolas Ruggli、喜田宏
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      20071021-20071023
  • [Presentation] 牛ウイルス性下痢ウイルスの生物現象の差によるゲノム塩基配列の相違2007

    • Author(s)
      小佐々隆志、青木博史、野田紗知子、関口秀人、福所秋雄、中村成幸
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      20071021-20071023
  • [Presentation] 豚コレラウイルスのCPK-NS細胞に対する病原性の解析2007

    • Author(s)
      伊藤麻子、迫田義博、Nicolas Ruggli、喜田宏
    • Organizer
      第144回日本獣医学会学術集会
    • Place of Presentation
      酪農学園大学、江別
    • Year and Date
      20070902-20090904

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Published: 2011-06-18   Modified: 2016-04-21  

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