2009 Fiscal Year Final Research Report

Possible pharmacokinetic drug-drug interaction during corticosteroid therapy in dogs

Research Project

Project/Area Number	19380176
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Clinical veterinary science
Research Institution	Tokyo University of Agriculture and Technology
Principal Investigator	SHIMODA Minoru Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (50154323)
Co-Investigator(Kenkyū-buntansha)	IWASAKI Toshiro 東京農工大学, 大学院・共生科学技術研究院, 教授 (50262754)
Project Period (FY)	2007 – 2009
Keywords	治療 / 薬物動態 / 薬物間相互作用 / 消炎ステロイド / イヌ
Research Abstract	In this study we examined possible pharmacokinetic drug-drug interaction by corticosteroid treatment in dogs. As a result, predonisolone, triamucinolone and hydrocortisone affected oxidative metabolism and the levels of drug binding protein in plasma. These corticosteroids may, therefore, result in adverse effects of some drugs, which are co-medicated, through altering biotransformation rate and distribution of the co-medicated drugs.

(3 results)