2010 Fiscal Year Final Research Report
Nano molecular design for functionalized nucleotides and peptides
| Project/Area Number |
19390008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
SUEMUNE Hiroshi Kyushu University, 薬学研究院, 教授 (20095897)
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| Co-Investigator(Kenkyū-buntansha) |
ASO Mariko 九州大学, 大学院・薬学研究院, 准教授 (30201891)
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| Project Period (FY) |
2007 – 2010
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| Keywords | らせん分子 / ナノ分子 / 核酸 / ペプチド |
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| Research Abstract |
The followings are purposes of this project. Using the nucleotides and peptides, synthesis of novel Nano-helix functional molecules and its structural analysis. 1. Synthesis of optically active alpha-, alpha-disubstituted cyclic alpha-amino acids, and its peptides ; 2. Development novel asymmetric reaction using Nano-helix structure. Above studies gave us fruitful results.
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Research Products
(86 results)
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[Journal Article] Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues2010
Author(s)
Demizu, Y., Tanaka M., Doi, M., Kurihara, M., Okuda, H., Suemune H.
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Journal Title
Journal of Peptide Science 16(11)
Pages: 621-626
Peer Reviewed
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[Journal Article] Computational study on helical structure of chiral α, α-disubstituted oligopeptides2010
Author(s)
Kurihara, M., Sato, Y., Yamagata, N., Demizu, Yosuke, Okuda, Haruhiro, Nagano, Masanobu, Doi, Mitsunobu, Tanaka Masakazu ; Suemune Hiroshi
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Journal Title
Peptide Science 2009
Pages: 385-386
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[Journal Article] Controlling the helical screw sense of peptides by N-terminal proline2010
Author(s)
Yamagata, N., Demizu, Y., Sato, Y., Oba, M., Tanaka M., Doi, M., Nagasawa, K., Suemune H., Okuda, H., Kurihara, M.
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Journal Title
Peptide Science 2009
Pages: 383-384
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[Journal Article] Conformational analysis of water-soluble oligopeptides composed of chiral cyclic α, α-disubstituted α-amino acids2010
Author(s)
Demizu, Y., Tanaka M., Suemune H., Doi, M., Sato, Y., Okuda, H., Kurihara, M.
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Journal Title
Peptide Science 2009
Pages: 381-382
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[Journal Article] Solid-state conformation of diastereomeric Pro-Pro-(Aib)4 sequences2010
Author(s)
Oba, M., Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka M., Suemune H., Okuda, H., Kurihara, M.
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Journal Title
Tetrahedron 66(13)
Pages: 2293-2296
Peer Reviewed
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[Journal Article] Computational Study on Helical Structure of Disubstituted Oligopeptides Containing Amino Acids2009
Author(s)
Kurihara, M., Sato, Y., Yamagata, N., Okuda, H., Nagano,M., Demizu, Y., Doi, M., Tanaka M., Suemune H.
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Journal Title
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[Journal Article] Design and synthesis of chiral cyclic α, α-disubstituted amino acid having azido functions, and its oligopeptides2009
Author(s)
Takazaki, H., Tanaka M., Kawabe, N., Nagano, M., Doi, M., Kurihara, M., Suemune H
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Journal Title
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[Journal Article] Synthesis of Nitroxylradicals for Overhuser-enhanced magnetic resonance imaging2008
Author(s)
K.Yamada, Y.Kinoshita, T.Yamasaki, H.Sadasue, F.Mito, M.Nagai, S.Matsumoto, M.Aso, H.Suemune, K.Sakai, H.Utsumi
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Journal Title
Arch.Pharm. 341(9)
Pages: 548-553
Peer Reviewed
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