2010 Fiscal Year Final Research Report
Chemical biology of collagen toward drug development
| Project/Area Number |
19390032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Waseda University |
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Principal Investigator |
KOIDE Takaki Waseda University, 理工学術院, 教授 (70322253)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Kouki 新潟薬科大学, 薬学部, 教授 (60093853)
ASADA Shinichi 新潟薬科大学, 薬学部, 助教 (50424883)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 医薬分子設計 / ペプチド / コラーゲン / スクリーニング / タンパク質 |
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| Research Abstract |
We have developed a facile high-throughput screening system to obtain inhibitors for collagen-protein interactions. By using this system, we obtained inhibitors for HSP47 (collagen-specific chaperone), GPVI (platelet collagen receptor), VWF (blood coagulation factor), and clostridial collagenase (exotoxin causing gas gangrene). Results obtained from a structure-activity relationship study of PEDF-binding peptides have implied involvement of heparan sulfate proteoglycans in PEDF's anti-angiogenic activity.
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