2009 Fiscal Year Final Research Report
The critical role of inflammation in angiogenesis and malignant progression by cancer cells through altered tumor microenvironment
| Project/Area Number |
19390089
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
ONO Mayumi Kyushu University, 薬学研究院, 客員教授 (80128347)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 炎症 / がん / 血管新生 / がん微小環境 / リンパ管新生 |
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| Research Abstract |
Increasing evidence confirms that chronic inflammation is the strongest link to cancer. In 1850, Rudolf Virchow from Wurzburg, Germany, was the first to link chronic inflammation with arthritis, obesity, asthma and cancer. We observed that inflammatory cytokines, IL-1β, could induce angiogenesis and lymphangiogenesis through activation of transcription factor, NF-κB and proinflammatory gene products. Enhanced angiogenesis resulted in tumor progression with macrophage infilteration and this was inhibited by macrophage targeting drugs.
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[Journal Article] Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.2010
Author(s)
Murakami, Y., Hosoi, F., Izumi, H., Maruyama, Y., Ureshino, H., Watari, K., Kohno, K., Kuwano, M., Ono, M.
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Journal Title
Biochem. and Biophys. Res Commun. (In press)
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[Journal Article] Suppressioni of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis.2009
Author(s)
Taniguchi, K., Sasaki, K., Watari, K., Yasukawa, H., Imaizumi, T., Ayada, T., Okamoto, F., Ishizaki, T., Kato, R., Kohno, R., Kimura, H., Sato, Y., Ono, M., Yonemitsu, Y., Yoshimura, A.
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Journal Title
PLoS ONE. 4
Pages: e5467:1-11
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[Journal Article] N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of IKKbeta expression.2009
Author(s)
Hosoi, F., Izumi, H., Kawahara, A., Yuichi, M., Kinoshita, H., Kage, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M.
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Journal Title
Cancer Res. 69
Pages: 4983-4991
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[Journal Article] Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-κB activation.2008
Author(s)
Watari, K., Nakao, S., Fotovati, A., Basaki, Y., Hosoi, F., Bereczky, B., Higuchi, R., Miyamoto, T., Kuwano, M., Ono, M.
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Journal Title
Biochem. and Biophys. Res Commun. 377
Pages: 826-31
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[Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.2007
Author(s)
Kimura, Y., Watari, K., Fotovati, A., Hosoi, F., Yasumoto, K., Izumi, H., Kohno, K., Umezawa, K., Iguchi, H., Shirouzu, K., Takamori, S., Kuwano, M., Ono, M.
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Journal Title
Cancer Sci. 98
Pages: 2009-2018
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[Journal Article] Dexamethasone inhibits IL-1・-induced corneal neovascularization: role of NF-κB-activated stromal cells in inflammatory angiogenesis.2007
Author(s)
Nakao, S., Hata, Y., Miura, M., Noda, K., Kinura, Y., Kawahara, S., Kita, T., Hisatomi, T., Nakazawa, T., Jin, Y., Dana, R., Kuwano, M., Ono, M., Ishibashi, T., Hafezi-Moghadam, A.
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Journal Title
Am. J. Path. 171
Pages: 1058-1065
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