2009 Fiscal Year Final Research Report
Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse models
| Project/Area Number |
19390114
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
TSUCHIMOTO Daisuke Kyushu University, 生体防御医学研究所, 助教 (70363348)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKABEPPU Yusaku 九州大学, 生体防御医学研究所, 教授 (30180350)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 動物 |
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| Research Abstract |
We have revealed various roles of DNA repair enzymes or nucleotide pool sanitizing enzymes in immune cells, tumor suppression, suppression or induction of neural cell death in Hantington disease, development, and cell death induction and suppression under oxidative stress. We also identified and analyzed novel nuclotide pool sanitizing enzymes, RS21-C6 and NUDT16.
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[Journal Article] A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.2008
Author(s)
De Luca G, Russo MT, Degan P, Tiveron C, Zijno A, Meccia E, Ventura I, Mattei E, Nakabeppu Y, Crescenzi M, Pepponi R, Pezzola A, Popoli P, Bignami M.
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Journal Title
PLoS Genet. 4(11)
Pages: e1000266
Peer Reviewed
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[Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.2007
Author(s)
Sakamoto K, Tominaga Y, Yamauchi K, Nakatsu Y, Sakumi K, Yoshiyama K, Egashira A, Kura S, Yao T, Tsuneyoshi M, Maki H, Nakabeppu Y(共同責任著者), Tsuzuki T.
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Journal Title
Cancer Res. 67(14)
Pages: 6599-604
Peer Reviewed
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