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2009 Fiscal Year Final Research Report

Development of preventive and therapeutic method of asthma by the regulation of arginase

Research Project

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Project/Area Number 19390163
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionOkayama University

Principal Investigator

OGINO Keiki  Okayama University, 大学院・医歯薬学総合研究科, 教授 (70204104)

Co-Investigator(Kenkyū-buntansha) OU Tatsuko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (90294404)
TAKIGAWA Tomoko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (90403493)
MAEKAWA Tuyoshi  山口大学, 大学院・医学系研究科, 教授 (60034972)
IZUMI Tomonori  山口大学, 医学系研究科, 准教授 (00261694)
SASAKI Kenji  岡山大学, 大学院・医歯薬学総合研究科, 教授 (20116461)
OUCHI Kazunobu  川崎医科大学, 医学部, 教授 (80351899)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA Kazuyuki  山口大学, 大学院・医学系研究科, 教授 (90107748)
Project Period (FY) 2007 – 2009
Keywords環境保健 / 予防医学 / 環境生理
Research Abstract

We demonstrated that the deletion of nitric oxide as a bronchodilator in asthma was contributed to consumption of arginine and low generation of nitric oxide from nitric oxide synthase from upregulated arginase in mite-induced mice asthma model by inoculation of anti-IL-13 monoclonal antibody and an arginase inhibitor. Moreover, it was demonstrated that in human asthma increased serum arginase levels regulated serum arginine levels and exhaled nitric oxide.

  • Research Products

    (16 results)

All 2010 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results)

  • [Journal Article] Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.2010

    • Author(s)
      Takahashi N, Ogino K, Takemoto K, Hamanishi S, Wang DH, Takigawa T, Shibamori M, Ishiyama H, Fujikura Y
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol (in press)

    • Peer Reviewed
  • [Journal Article] Efficient assay for total antioxidant capacity in human plasma using a 96-well microplate.2009

    • Author(s)
      Kambayashi Y, Binh NT, W Asakura H, Hibino Y, Hitomi Y, Nakamura H, Ogino K
    • Journal Title

      J Clin Biochem Nutr 44

      Pages: 46-51

    • Peer Reviewed
  • [Journal Article] Preparation and Characterization of a Polyclonal Antibody against Brominated Protein.2009

    • Author(s)
      Kambayashi Y, Ogino K, Takemoto K, Imagama T, Takigawa T, Kimura S, Hibino Y, Hitomi Y, Nakamura H.
    • Journal Title

      J Clin Biochem Nutr 44(1)

      Pages: 95-103

    • Peer Reviewed
  • [Journal Article] Biomarkers of oxidative/nitrosative stress: an approach to disease prevention.2007

    • Author(s)
      Ogino K, Wang DH
    • Journal Title

      Acta Med Okayama. 61

      Pages: 181-189

    • Peer Reviewed
  • [Journal Article] Biochemical characterization of reactive nitrogen species by eosinophil peroxidase in tyrosine nitration.2007

    • Author(s)
      Takemoto K, Ogino K, Wang DH, Takigawa T, Kurosawa CM, Kamyabashi Y, Hibino Y, Hitomi Y, Ichimura H
    • Journal Title

      Acta Med Okayama 61

      Pages: 17-30

    • Peer Reviewed
  • [Journal Article] Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.2007

    • Author(s)
      Takemoto K, Ogino K, Shibamori M, Gondo T, Hitomi Y, Takigawa T, Wang DH, Takaki J, Ichimura H, Fujikura Y, Ishiyama H
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 293

      Pages: L1419-26

    • Peer Reviewed
  • [Journal Article] NC/Ngaマウス喘息モデルの特徴.2007

    • Author(s)
      荻野景規
    • Journal Title

      喘息 22

      Pages: 40-43

    • Peer Reviewed
  • [Journal Article] 3-ニトロチロシン2007

    • Author(s)
      荻野景規
    • Journal Title

      岡山医学会雑誌 118

      Pages: 225-234

    • Peer Reviewed
  • [Presentation] ダニ蛋白誘発喘息におけるステロイド剤の効果;NOとアルギナーゼの関係2009

    • Author(s)
      宗友一晃、竹本圭、吉田純子、張燃、鄒宇、瀧川智子、汪達紘、高木二郎、荻野景規
    • Organizer
      第7回日本予防医学会学術総会
    • Place of Presentation
      千葉市
    • Year and Date
      20091212-20091215
  • [Presentation] カタラーゼ投与による実験的潰瘍性大腸炎症の緩和2009

    • Author(s)
      赤澤裕二、荻野景規、竹本圭、汪達紘、瀧川智子
    • Organizer
      第7回日本予防医学会学術総会
    • Place of Presentation
      千葉市
    • Year and Date
      20091212-20091214
  • [Presentation] アルギナーゼ阻害による実験的喘息の抑制2009

    • Author(s)
      高橋紀子、竹本圭、濱西誠司、ラニサウリアサリ、柴森雅文、汪達紘、瀧川智子、高木二郎、石山広信、荻野景規
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-31
  • [Presentation] アルギナーゼ欠損マウスにおける実験的潰瘍性大腸炎症状の評価2009

    • Author(s)
      赤澤裕二、荻野景規、竹本圭、汪達紘、高橋紀子、高木二郎、瀧川智子
    • Organizer
      第79回日本衛生学会学術総会
    • Place of Presentation
      東京都
    • Year and Date
      2009-03-31
  • [Presentation] アルギナーゼの特異的な阻害剤であるNor-NOHAの喘息モデルMc/Ngaマウスへの投与による効果2008

    • Author(s)
      濱西誠司、竹本圭、高橋紀子、ラニサウリアサリ、柴森雅文、汪達紘、荻野景規
    • Organizer
      第6回日本予防医学会学術総会
    • Place of Presentation
      東京都
    • Year and Date
      2008-11-30
  • [Presentation] 喘息増悪因子としてのアルギナーゼ誘導-NC/Ngaマウス喘息モデルを用いた検討2008

    • Author(s)
      竹本圭、黒澤カルメン、濱西誠司、柴森雅文、高木二郎、瀧川智子、汪達紘、荻野景規
    • Organizer
      第8回日本NO学会学術集会
    • Place of Presentation
      仙台市
    • Year and Date
      2008-05-10
  • [Presentation] NOの枯渇は喘息の病態に重要な影響をもたらすか?2007

    • Author(s)
      竹村洋子、竹本圭、瀧川智子、汪達紘、荻野景規
    • Organizer
      第7回日本NO学会学術集会
    • Place of Presentation
      大津市
    • Year and Date
      20070517-20070518
  • [Presentation] IL-13モノクローナル抗体によるアルギナーゼi阻害はNC/Ngaマウスのアレルギー喘息様反応を抑制する2007

    • Author(s)
      黒沢カルメン、柴森雅文、石山広信、竹本圭、王炳玲、濱西誠司、ラニサウリアサリ、瀧川智子、汪達紘、高木二郎、荻野景規
    • Organizer
      第78回日本衛生学会
    • Place of Presentation
      熊本市
    • Year and Date
      2007-03-31

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Published: 2011-06-18   Modified: 2014-09-19  

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