Large prospective cohort study for the pro-oxidant and antioxidant factors and atherosclerotic disease.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390174
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka University
• Principal Investigator: ISO Hiroyasu Osaka University, 医学系研究科, 教授 (50223053)
• Co-Investigator(Kenkyū-buntansha): INOUE Manami 国立がん研究センター, がん予防・検診研究センター, 室長 (70250248) ; TAMAKOSHI Akiko 愛知医科大学, 医学部・公衆衛生学, 准教授 (90236737) ; KOIKE Kazuko 植草学園大学, 保健医療学部, 教授 (60110508) ; DATE Chigusa 奈良女子大学, 生活環境部, 教授 (60047389) ; KITAMURA Akihiko (財)大阪府保健医療財団大阪府立健康科学センター, 健康開発部, 部長 (80450922) ; YAMAGISHI Kazumasa 筑波大学, 人間総合科学研究科, 講師 (20375504) ; SAKURAI Naomi 茨城県立医療大学, 保健医療学部, 准教授 (10274979)
• Project Period (FY): 2007 – 2009
• Keywords: 動脈硬化 / 酸化 / 生活習慣 / リスク / コホート研究

Research Abstract

To examine potential effects of the pro-oxidant and antioxidant factors on the atherosclerotic disease, we conducted prospective studies for the incidence of and mortality from stroke and coronary heart disease using stored blood samples among 70,000 Japanese men and women aged 40-79. Also, we built a nutritional database and examined the association of antioxidant foods and nutritions with atherosclerotic disease incidence and mortality. We identified pro-oxidant factors (high level of hs-CRP and C. pneumoniae antibody titers of IgA) and antioxidant factors (fish, n-3 unsaturated fatty acids and vitamins A, B, C and E intakes) on atherosclerotic disease incidence and mortality.

Research Products

• [Journal Article] Japan Collaborative Cohort Study Group. Dietary Folate and Vitamin B6 and B12 Intake in Relation to Mortality From Cardiovascular Diseases. (2010)
  • Author(s): Cui R, Iso H, Date C, Kikuchi S, Tamakoshi A
  • Journal Title: Japan Collaborative Cohort Study (in press)
  • Peer Reviewed
• [Journal Article] Serum vitamin C concentration and hs-CRP level in middle-aged Japanese men and women. (2010)
  • Author(s): Kubota Y, Moriyama Y, Yamagishi K, Tanigawa T, Noda H, Iso H (11人中3番目, 11番目)
  • Journal Title: Atherosclerosis 208 Pages: 496-500
  • Peer Reviewed
• [Journal Article] JACC Study Group. C-reactive protein levels and risk of mortality from cardiovascular disease in Japanese: the JACC Study. (2009)
  • Author(s): Iso H, Cui R, Date C, Kikuchi S, Tamakoshi A
  • Journal Title: Atherosclerosis 207 Pages: 291-297
  • Peer Reviewed
• [Journal Article] Fruit, vegetable and bean intake and mortality from cardiovascular disease among Japanese men and women: the JACC Study. (2009)
  • Author(s): Nagura J, Iso H, Watanabe Y, Maruyama K, Date C, Tamakoshi A (13人中2番目、5番目、13番目)
  • Journal Title: Br J Nutr 102 Pages: 285-292
  • Peer Reviewed
• [Journal Article] Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study. (2008)
  • Author(s): Cui R, Moriyama Y, Koike KA, Date C, Tamakoshi A, Iso H (7人中3番目, 4番目, 6番目, 7番目)
  • Journal Title: Atherosclerosis 198 Pages: 412-418
  • Peer Reviewed
• [Journal Article] Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study. (2008)
  • Author(s): Yamagishi K, Iso H, Date C, Fukui M, Wakai K, Tamakoshi A (9人中1番目, 2番目, 3番目, 9番目)
  • Journal Title: J Am Coll Cardiol 52 Pages: 988-996
  • Peer Reviewed
• [Journal Article] Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I. (2008)
  • Author(s): Ishihara J, Iso H, Inoue M, Iwasaki M, Okada K, Kita Y (9人中2番目, 3番目)
  • Journal Title: J Am Coll Nutr 27 Pages: 127-136
  • Peer Reviewed
• [Journal Article] JPHC Study Group. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. (2007)
  • Author(s): Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S
  • Journal Title: Circulation 116 Pages: 2553-2562
  • Peer Reviewed
• [Journal Article] Chlamydia pneumoniae infection was associated with risk of mortality from coronary heart disease in Japanese women but not men: the JACC Study.
  • Author(s): Sakurai-Komada N, A Koike K, Kaku Y, Date C, Iso H, Tamakoshi A (10人中1番目, 2番目, 8番目, 9番目, 10番目)
  • Journal Title: J Atheroscl Thromb 2010(in press)
  • Peer Reviewed
• [Presentation] 高感度CRPとの脳卒中発症との関連:地域住民におけるNested-case control study (2009)
  • Author(s): チェイチョイライ, 山岸良匡, 北村明彦, 他
  • Organizer: 第68回日本公衆衛生学会
  • Place of Presentation: 奈良
  • Year and Date: 2009-10-22
• [Presentation] Interrelationship between serum vitamin C and hs-CRP levels in middle-aged Japanese men and women. (2009)
  • Author(s): Kubota Y, Moriyama Y, Yamagishi Y, et. al.
  • Organizer: The First Asia-Pacific Conference on Health Promotion and Education
  • Place of Presentation: 千葉
  • Year and Date: 2009-07-18