2009 Fiscal Year Final Research Report
Gut microbiota and Host Stress Response
| Project/Area Number |
19390192
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kyushu University |
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Principal Investigator |
KUBO Chiharu Kyushu University, 大学病院, 教授 (80117100)
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| Co-Investigator(Kenkyū-buntansha) |
SUDO Nobuyuki 九州大学, 大学院・医学研究院, 教授 (60304812)
YOSHIHARA Kazufumi 九州大学, 大学病院, 助教 (20444854)
KOGA Yasuhiro 東海大学, 医学部, 教授 (60170221)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 生理学 / ストレス / 神経科学 / 腸内細菌 |
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| Research Abstract |
Our previous works on germ-free and gnotobiotic mice demonstrate that gut microbiota can affect the development of hypothalamic-pituitary-adrenal reaction to stress. In this study, behavioral analysis was further investigated using these mice. In addition, we also examined the effects of maternal fecal and vaginal flora on infant salivary cortisol levels. As a result, germ-free mice were more anxious than Ex-GF mice which were reconstituted with SPF feces. Regarding salivary cortisol levels in human babies, they were negatively correlated with the ratio of Bifidobacterium to Lactobacillus in maternal cervical swabs.
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