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2009 Fiscal Year Final Research Report

Neuropathogenesis of retrovirus infection : diverse in vivo and ex vivo analysis of HAM/TSP and AIDS encephalopathy.

Research Project

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Project/Area Number 19390243
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKagoshima University

Principal Investigator

IZUMO Shuji  Kagoshima University, 大学院・医歯学総合研究科, 教授 (30143811)

Co-Investigator(Kenkyū-buntansha) KUBOTA Ryuji  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (70336337)
HURUKAWA Yoshitaka  鹿児島大学, 医学部・歯学部附属病院, 講師 (00359978)
OKAMOTO Mika  鹿児島大学, 大学院・医歯学総合研究科, 講師 (90336347)
ARIMURA Kimiyoshi  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (20159510)
UMEHARA Hujio  鹿児島大学, 大学院・医歯学総合研究科, 講師 (20271140)
Co-Investigator(Renkei-kenkyūsha) MORI Kazuyasu  国立感染症研究所, エイズ研究センター, 主任研究員 (20270655)
Project Period (FY) 2007 – 2009
KeywordsHTLV-1 / HIV-1 / HAM / TSP / エイズ脳症 / 発症病態 / 治療法
Research Abstract

In order to clarify neuropathogenesis of retrovirus-induced neurological disorders we performed diverse in vivo and ex vivo analysis of HAM/TSP and AIDS encephalopathy. We demonstrated presence of infected mononuclear cells and accumulation of virus-specific cytotoxic T lymphocytes in the inflammatory lesions of HAM/TSP. Additional studies on AIDS encephalopathy, as well as HTLV-1-associated polymyositis, suggest that invasion of infected mononuclear cells in the site of the nervous system and immune responses against these infected cells is a common pathogenic process of retrovirus induced neurological disorders. We also demonstrated that degeneration of the cerebral cortex occurs in AIDS encephalopathy independently from the inflammatory process, and dysfunction of astrocytes may have a role in this degenerative process.

  • Research Products

    (22 results)

All 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Expression of proinflammatory cytokines and its relationship with virus infection in the brain of macaques inoculated with macrophage-tropic simian immunodeficiency virus.2009

    • Author(s)
      Xing HQ, Moritoyo T, Mori K, Sugimoto C, Ono F, Izumo S
    • Journal Title

      Neuropathology 29

      Pages: 13-19

    • Peer Reviewed
  • [Journal Article] Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis.2009

    • Author(s)
      Xing HQ, Hayakawa H, Gelpi E, Kubota R, Budka H, Izumo S
    • Journal Title

      J Neuropathol Exp Neurol 68

      Pages: 199-209

    • Peer Reviewed
  • [Journal Article] In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases.2009

    • Author(s)
      Xing HQ, Hayakawa H, Izumo K, Kubota R, Gelpi E, Budka H, Izumo S
    • Journal Title

      Neuropathology 29

      Pages: 433-442

    • Peer Reviewed
  • [Journal Article] Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan.2008

    • Author(s)
      Matsuura E, Umehara F, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M
    • Journal Title

      J Neuropathol Exp Neurol 67

      Pages: 41-49

    • Peer Reviewed
  • [Journal Article] Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy.2008

    • Author(s)
      Hayashi D, Kubota R, Takenouchi N, Tanaka Y, Hirano R, Takashima H, Osame M, Izumo S, Arimura K
    • Journal Title

      J Neuroimmunol 200

      Pages: 115-124

    • Peer Reviewed
  • [Journal Article] Impaired astrocytes and diffuse activation of microglia in the cerebral cortex in simian immunodeficiency virus-infected Macaques without simian immunodeficiency virus encephalitis.2008

    • Author(s)
      Xing HQ, Mori K, Sugimoto C, Ono F, Izumo K, Kuboda R, Izumo S
    • Journal Title

      J Neuropathol Exp Neurol 67

      Pages: 600-611

    • Peer Reviewed
  • [Journal Article] mpaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease.2008

    • Author(s)
      Sabouri AH, Usuku K, Hayashi D, Izumo S, Ohara Y, Osame M, Saito M
    • Journal Title

      Blood 112

      Pages: 2411-2420

    • Peer Reviewed
  • [Journal Article] Highly enhanced expression of CD70 on human T-lymphotropic virus type 1-carrying T-cell lines and adult T-cell leukemia cells.2008

    • Author(s)
      Baba M, Okamoto M, Hamasaki T, Horai S, Wang X, Ito Y, Suda Y, Arima N
    • Journal Title

      J Virol 82

      Pages: 3843-3852

    • Peer Reviewed
  • [Journal Article] Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs.2007

    • Author(s)
      Kubota R, Hanada K, Furukawa Y, Arimura K, Osame M, Gojobori T, Izumo S
    • Journal Title

      J Immunol 178

      Pages: 5966-5972

    • Peer Reviewed
  • [Journal Article] Safety and efficacy of interferon-alpha in 167 patients with human T-cell lymphotropic virus type 1-associated myelopathy.2007

    • Author(s)
      Arimura K, Nakagawa M, Izumo S, Usuku K, Itoyama Y, Kira J, Osame M
    • Journal Title

      J Neurovirol 13

      Pages: 364-372

    • Peer Reviewed
  • [Presentation] HTLV-I感染者における免疫抑制性受容体の発現2009

    • Author(s)
      吉満誠, 小迫知弘, 鈴木伸介, 松下格司, 魚住公治, 久保田龍二, 出雲周二, 有馬直道
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-08-29
  • [Presentation] HTLV-I関連脊髄症(HAM/TSP)におけるRNAマイクロアレイ解析による検討2009

    • Author(s)
      児玉大介, 久保田龍二, 出雲周二
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-08-29
  • [Presentation] HTLV-Iキャリア外来の現状とHAM患者の動向について2009

    • Author(s)
      松崎敏男, 久保田龍二, 有村公良, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-21
  • [Presentation] 抗原認識特異度の低いHTLV-I特異的CTLはウイルス淘汰圧が高い2009

    • Author(s)
      久保田龍二, 松浦英治, 有村公良, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-20
  • [Presentation] HTLV-I関連脊髄症(HAM/TSP)患者末梢血単核球を用いた合胞体形成の検討2009

    • Author(s)
      児玉大介, 久保田龍二, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-20
  • [Presentation] 炎症性サイトカインTNF-αとIL-1βのエイズ脳症への関与;サルエイズモデルでの検討2008

    • Author(s)
      〓惠琴, 森一泰, 出雲周二
    • Organizer
      第49回日本神経病理学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-05-21
  • [Presentation] シンポジウム3: HAARTとNeuroAIDS。NeuroAIDSとサイトカイン:ヒト剖検例とサルエイズモデルをもちいた免疫組織学的検討2008

    • Author(s)
      出雲周二
    • Organizer
      第22回日本エイズ学会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-05-15
  • [Presentation] HLA-A24はHAMでは頻度が高いがウイルス量は低い2008

    • Author(s)
      久保田龍二
    • Organizer
      第49回日本神経学会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-05-15
  • [Presentation] エイズ脳症病巣における炎症性サイトカインの発現:サルエイズモデルを用いた解析2008

    • Author(s)
      Xing, HuiQin, 森一泰, 出雲周二
    • Organizer
      第20回日本神経免疫学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2008-04-18
  • [Presentation] 教育講演03:HIV感染における神経障害:エイズ脳症の発症機序を中心に2007

    • Author(s)
      出雲周二
    • Organizer
      第21回日本エイズ学会学術集会
    • Place of Presentation
      広島市
    • Year and Date
      2007-11-29
  • [Book] 今日の治療指針2010年版「私はこうして治療している」2010

    • Author(s)
      出雲周二
    • Total Pages
      768-770
    • Publisher
      医学書院
  • [Book] 第III章HTLV-1関連疾患HAM/TSPの疫学と臨床像, 病理, 治療2007

    • Author(s)
      出雲周二(分担)
    • Total Pages
      96-105
    • Publisher
      文光堂

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Published: 2011-06-18   Modified: 2016-04-21  

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