2009 Fiscal Year Final Research Report
Leukemogenesis due to insertional mutagenesis-a NOG mouse model-
| Project/Area Number |
19390280
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tohoku University |
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Principal Investigator |
TSUCHIYA Shigeru Tohoku University, 大学院・医学系研究科, 教授 (30124605)
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| Project Period (FY) |
2007 – 2009
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| Keywords | NOGマウス / 遺伝子治療 / レトロウイルスベクター / LMO2 / MLL / AF10 / 白血病 / k-ras / セカンドヒット |
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| Research Abstract |
Humanized NOD/shi-scid/gammac (null) (NOG) mice (hu-HSC NOG mice) model was established in order to know the safety and efficacy of human gene therapy. We found that LMO-2 gene-introduced human cord blood stem cells showed transient proliferation in NOG mice, but did not induce leukemia at all. The conclusion is that the second hit by an additional oncogene must be required to complete the leukemogenic process.
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[Journal Article] Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders : dephosphorylation of serine 259 as the essential mechanism for mutant activation2010
Author(s)
Kobayashi T, Aoki Y, Niihori T, Cave H, Verloes A, Okamoto N, Kawame H, Fujiwara I, Takada F, Ohata T, Sakazume S, Ando T, Nakagawa N, Lapunzina P, Meneses AG, Gillessen-Kaesbach G, Wieczorek D, Kurosawa K, Mizuno S, Ohashi H, David A, Philip N, Guliyeva A, Narumi Y, Kure S, Tsuchiva S, Matsubara Y.
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Journal Title
Hum Mutat. 31(3)
Pages: 284-94
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[Journal Article] Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia2009
Author(s)
Horino S, Rikiishi T, Niizuma H, Abe H, Watanabe Y, Onuma M, Hoshi Y, Sasaharn Y, Yoshinari M, Kazama T, Hayashi Y, Kumaki S, Tsuchiva S.
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Journal Title
Int J Hematol. 90(4)
Pages: 483-5
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[Journal Article] Risk-stratified therapy and the intensive use of cytarabinc improves the outcome in childhood acute myeloid leukemia : the AML99 trial from the Japanese Childhood AML Cooperative Study Group2009
Author(s)
Tsukimoto I, Tawa A, Horibe K, Tabuchi K, Kigasawa H, Tsuchida M, Yabe H, Nakayama H, Kudo K, Kobayashi R, Hamamoto K, Imaizumi M, Morimoto A, Tsuchiva S, Hanada R.
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Journal Title
J Clin Oncol. 27(24)
Pages: 4007-13
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[Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice)2009
Author(s)
Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiva S, Sugamura K.
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Journal Title
Int Imunol. 21(7)
Pages: 843-58
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[Journal Article] Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome2009
Author(s)
Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiva S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H.
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Journal Title
J Exp Med. 206(6)
Pages: 1291-301
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[Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome2007
Author(s)
Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
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Journal Title
Nature 448(7147)
Pages: 1058-62
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[Presentation] 免疫不全症に合併した悪性リンパ腫2例2008
Author(s)
青木由貴, 遠藤明史, 満生紀子, 小野敏明, 磯田健志, 冨澤大輔, 高木正稔, 梶原道子, 長澤正之, 森尾友宏, 水谷修紀, 笹原洋二, 久間木悟, 土屋滋, 大石力
Organizer
第50回日本小児血液学会
Place of Presentation
幕張メッセ国際会議場
Year and Date
20081114-20081116
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[Presentation] 小児造血幹細胞移植登録事業における移植成績の解析20082008
Author(s)
田渕健, 気賀沢寿人, 吉見礼美, 足立壮一, 磯山恵一, 井上雅美, 加藤剛二, 河野嘉文, 菊池陽, 小林良二, 土屋滋, 堀越泰雄, 矢部普正, 渡辺新, 加藤俊一
Organizer
第50回日本小児血液学会
Place of Presentation
幕張メッセ国際会議場
Year and Date
20081114-20081116
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[Presentation] 慢性活動性EBV感染症の4例2008
Author(s)
渡辺祐子, 阿部弘, 新妻秀剛, 星能元, 力石健 笹原洋二, 坂本修, 吉成みやこ, 久間木悟, 土屋滋
Organizer
第111回日本小児科学会学術集会
Place of Presentation
東京国際フォーラム
Year and Date
20080425-20080427
