2009 Fiscal Year Final Research Report
Maternal leukemia inhibitory factor regulates fetal brain development via a maternal-fetal signaling pathway
| Project/Area Number |
19390291
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
HATTA Toshihisa Kanazawa Medical University, 医学部, 教授 (20238025)
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| Co-Investigator(Kenkyū-buntansha) |
OTANI Hiroki 島根大学, 医学部, 教授 (20160533)
HASHIMOTO Ryuju 島根大学, 医学部, 助教 (90252907)
UDAGAWA Jun 島根大学, 医学部, 助教 (10284027)
MATSUMOTO Akihiro 島根大学, 医学部, 助教 (70346378)
SIMAMURA Eriko 金沢医科大学, 医学部, 講師 (00267741)
SHIMADA Hiroki 金沢医科大学, 医学部, 講師 (60278108)
HIGASHI Nobuaki 金沢医科大学, 医学部, 講師 (00139784)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 白血病抑制因子 / 副腎皮質刺激ホルモン / 胎盤 / 脳 / 赤血球 / 発生 |
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| Research Abstract |
Placental trophoblasts in rats are stimulated by maternal leukemia inhibitory factor (LIF) to secrete adrenocorticotropic hormone (ACTH) into the fetal blood circulation. Then, fetal nucleated red blood cells are reactive to placental ACTH to secrete LIF, which induces an increase of LIF level in the fetal cerebrospinal fluid. Finally, the neuron production in the fetal forebrain increased.
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Research Products
(41 results)
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[Journal Article] Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase.2009
Author(s)
Shimada H, Hirai K-I, Simamura E, Hatta T, Iwakiri H, Mizuki K, Hatta T, Sawasaki T, Matsunaga S, Endo Y, Shimizu S
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Journal Title
J Biol Chem 284
Pages: 28642-28649
Peer Reviewed
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[Presentation] 標準型腹腔動脈について2009
Author(s)
東伸明, 島田ひろき, 島村英理子, 八田稔久
Organizer
第69回中部支部学術集会(解剖誌,84:57)
Place of Presentation
浜松, 浜松医科大学
Year and Date
20091010-20091011
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