2009 Fiscal Year Final Research Report
Quantification of ferritin iron and its application to molecular imaging using high field MRI
| Project/Area Number |
19390327
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
MITSUMORI Fumiyuki National Institute for Environmental Studies, 化学環境研究領域, 室長 (90125229)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hidehiro 独立行政法人国立環境研究所, 化学環境研究領域, 主任研究員 (60370269)
UMEZU Toyoshi 独立行政法人国立環境研究所, 化学環境研究領域, 主任研究員 (00223610)
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| Research Collaborator |
TAKAYA Nobuhiro (株)エンテックスマイケルガーウツド・University of Minnesota, Michael Gareood
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| Project Period (FY) |
2007 – 2009
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| Keywords | 高磁場MRI / 生体分子 / フェリチン / 磁性 / 分子イメージング |
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| Research Abstract |
We developed a pulse sequence of MASE, which enables us to measure apparent transverse relaxation rates (R_2^†) of the water molecule at high field MRI. R_2^† values obtained in human brain was well described with a linear combination of regional iron concentration ([Fe]) and macromolecular fraction (f_M), R_2^†=α[Fe]+βf_M+γ, where α, β, and γ are coefficients. Brain regional iron concentration can be accurately quantified using the equation and experimentally determined coefficients.
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