Tissue engineered allograft tissue to prevent contamination

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390360
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: MOTOMURA Noboru The University of Tokyo, 医学部附属病院, 講師 (40332580)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Arata 東京大学, 医学部附属病院 (70190874)
• Project Period (FY): 2007 – 2009
• Keywords: 心臓大血管外科学 / 移植・再生医療 / 細胞・組織 / 微生物 / 放射線 / 外科

Research Abstract

Disinfection of cardiovascular tissues, like cardiac valve or vessels, by using radiation of gamma radiation was tried. Gamma radiation of 2kGy or 4kGy was applied to MRSA suspensions, resulting in no MRSA was detected. Then X-ray was used because X-ray is easier than gamma radiation in the usual hospitals. MRSA could be reduced with 100Gy of X-ray, and MRSA could be reduced in 16% by 400Gy of X-radiation. At 400Gy X-radiation, growth of cultured smooth muscle cells was not deteriorated.

Research Products

• [Journal Article] Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway (2009)
  • Author(s): Narui K, Noguchi N, Saito A, Kakimi K, Motomura N, Kubo K, Takamoto S, Sasatsu M.
  • Journal Title: Biol Pharm Bull 32 Pages: 41-44
  • Peer Reviewed
• [Journal Article] Toward quality improvement of thoracic aortic surgery : estimating volume-outcome effect from national clinical database (2009)
  • Author(s): Miyata H, Motomura N. Ueda Y, Tsukihara H, Tabayashi K, Takamoto S.
  • Journal Title: Eur J Cardiothorac Surg
  • Peer Reviewed
• [Journal Article] 外科における先進医療と高度医療。3. 同種心臓弁・血管移植と先進医療 (2009)
  • Author(s): 本村昇
  • Journal Title: 外科 71 Pages: 594-597
• [Journal Article] The Risk Model of Thoracic Aortic Surgery in 4707 Cases from Single Race Nationwide Population, via Web-based Data Entry System : a First Report of 30-day and Operative Outcome Risk Model on Thoracic Aortic Surgery (2008)
  • Author(s): Motomura N, Takamoto S, Miyata H, Tsukihara H, Okada M, Kiuchi T, Organization J.
  • Journal Title: Circulation. 118 (Suppl 1) Pages: S153-9
  • Peer Reviewed
• [Journal Article] Organization JCSD. Japan Adult Cardiovascular Surgery Database : First Report on 30-day and Operative Mortality Rates in Risk Models of Isolated CABG in Japanese (2008)
  • Author(s): Motomura N, Miyata H, Takamoto S, Okada M
  • Journal Title: Annals Thorac Surg. 86 Pages: 1866-72
  • Peer Reviewed
• [Journal Article] Vascular Allografts are Resistant to Methicillin-resistant Staphylococcus aureus via Indoleamine 2,3-Dioxygenase in Murine Model (2008)
  • Author(s): Saito A, Motomura N, Kakimi K, Narui K, Noguchi N, Sasatsu M, Kubo K, Koezuka Y, Takai D, Ueha S, Takamoto S.
  • Journal Title: J Thorac Cardiovasc Surg. 136 Pages: 159-67
  • Peer Reviewed
• [Journal Article] Effect of Procedural Volume on Outcome of CABG Surgery in Japan : Implication toward minimal volume standards and public reporting (2008)
  • Author(s): Miyata H, Motomura N. Ueda Y, Matsuda H, Takamoto S.
  • Journal Title: J Thorac Cardiovasc Surg. 135 Pages: 1306-12
  • Peer Reviewed
• [Journal Article] Diabetic Retinopathy and Coronary Artery Disease. From the Cardiac Surgeon's Perspective (2008)
  • Author(s): Ohno T, Takamoto S, Motomura N.
  • Journal Title: Annals Thorac Surg. 85 Pages: 681-9
  • Peer Reviewed
• [Journal Article] Toward quality improvement of cardiovascular surgery in Japan : An estimation of regionalization effects from a nationwide survey (2008)
  • Author(s): Miyata H, Motomura N. Kondo J, Fushimi K, Ishikawa B, Takamoto S.
  • Journal Title: Health Policy
  • Peer Reviewed
• [Journal Article] 循環器疾患のリスク管理 (2008)
  • Author(s): 宮田裕章, 本村昇, 月原弘之, 高本眞一
  • Journal Title: 心臓手術のリスク管理 呼吸と循環 56 Pages: 137-142
• [Journal Article] ホモグラフトを用いた大動脈基部置換術と体外循環法 (2007)
  • Author(s): 本村昇, 久保仁
  • Journal Title: Clinical Engineering 18 Pages: 989-996
• [Presentation] Local delivery of antibiotics incorporated in fibrin glue (2010)
  • Author(s): Motomura N, Saito A, Nawata K, Hisagi M, Kyo S, Ono M.
  • Organizer: 59^<Th> Annual Meeting of European Society for Cardiovascular Surgery
  • Place of Presentation: Izmir, Turkey
  • Year and Date: 2010-04-15
• [Presentation] Trend in clinical application of cryopreserved heart valve and vascular allografts (2009)
  • Author(s): Motomura N, Saito A, Tamura S, et al.
  • Organizer: American Association for Tissue Bank
  • Place of Presentation: Las Vegas
  • Year and Date: 2009-09-13
• [Presentation] Clinical results of valve and vascular allograft for cardiovascular diseases in the University of Tokyo (2007)
  • Author(s): Motomura N, Ono M, Yamauchi H, Masuzawa A, Karimov E, Ohtsubo A, Komiyama E, Takamoto S.
  • Organizer: 44^<th> Annual Meeting of the Society for Cryobiology Lake Louise
  • Place of Presentation: Canada
  • Year and Date: 2007-07-29
• [Presentation] Clinical results of valve and vascular allograft for cardiovascular diseases in the University of Tokyo (2007)
  • Author(s): Motomura N, Ono M, Saito A, Yamauchi H, Masuzawa A, Karimov E, Ohtsubo A, Komiyama E, Takamoto S.
  • Organizer: 15^<th> Annual Meeting Asian Society for Cardiovascular Surgery
  • Place of Presentation: Beijing
  • Year and Date: 2007-05-20