2009 Fiscal Year Final Research Report
Osteochondral regeneration using a scaffold-free tissue engineered construct (TEC) derived from mesenchymal stem cells
| Project/Area Number |
19390394
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA Norimasa Osaka University, 臨床医工学融合研究教育センター, 招聘教授 (50273719)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Jyun 大阪大学, 大学院・医学系研究科, 准教授 (40237938)
NAKATA Ken 大阪大学, 大学院・医学系研究科, 講師 (00283747)
YOSHIKAWA Hideki 大阪大学, 大学院・医学系研究科, 教授 (60191558)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIE Hiromichi 工学院大学, 工学部, 教授 (20199300)
AKASHI Mitsuru 大阪大学, 大学院・工学研究科, 教授 (20145460)
MTSUSAKI Michiya 大阪大学, 大学院・工学研究科, 講師 (00419467)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 幹細胞 / 軟骨分化 / 骨分化 / スキャフォールド / 再生医療 / メカニカルストレス / 骨形成因子 / ハイドロキシアパタイト |
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| Research Abstract |
We investigated the effect of scaffold-free tissue engineered construct (TEC) on osteochondral regeneration. We implanted either of the basic TEC, hydroxyapatite-adsorbed TEC, or hybrid material of the TEC and artificial bone (beta-TCP). Histological analysis at 4, 8 and 24 weeks following implantation revealed that the hybrid material of the TEC and artificial bone most effectively promoted osteochondral regeneration of the lesion. The TEC can adhere to the surface of artificial bone rapidly and stably, and further maintain hybrid condition in situ to promote osteochondral regeneration and thus could be a promising material for biological joint resurfacing.
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Research Products
(28 results)
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[Journal Article] Scaffold-Free Tissue-Engineered Construct-Hydroxyapatite Composites Generated by an Alternate Soaking Process: Potential for Repair of Bone Defects.2009
Author(s)
Matsusaki M, Kadowaki K, Tateishi K, Higuchi C, Ando W, Hart DA, Tanaka Y, Take Y, Akashi M, Yoshikawa H, Nakamura N
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Journal Title
Tissue Eng Part A 15
Pages: 55-63
Peer Reviewed
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