2009 Fiscal Year Final Research Report
ELUCIDATION OF MOLECULAR MECHANISMS UNDERLINING THE PROGRESSION OF PROSTATE CANCER ASSOCIATED WITH HIGH-FAT DIET
Project/Area Number |
19390411
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Akita University |
Principal Investigator |
HABUCHI Tomonori Akita University, 大学院・医学系研究科, 教授 (00293861)
|
Co-Investigator(Kenkyū-buntansha) |
SUZUKI Akira 九州大学, 生体防御研究所, 教授 (10311565)
NAKAMURA Akira 秋田大学, 大学院・医学系研究科, 教授 (20155815)
OYAMA Chikara 弘前大学, 大学院・医学系研究科, 教授 (80282135)
TSUCHIYA Norihiko 秋田大学, 大学院・医学系研究科, 准教授 (70282176)
YUASA Takeshi 財団法人癌研究会, 附属病院化学療法科, 医長 (00314162)
|
Project Period (FY) |
2007 – 2009
|
Keywords | 前立腺癌 / 高脂肪食 / マイクロアレイ / 発現解析 / IGF-1 / LNCaP / Fn-14 / TWEAK |
Research Abstract |
The purpose of this study project is to delineate the molecular mechanisms underlying the progression of prostate cancer associated with high-fat diet, and to identify molecular targets to prevent the high-fat associated progression of prostate cancer. As results, we found that the tumor growth of the LNCaP xenograft was markedly enhanced by high-fat diet. The several candidate target genes associated with the high-fat diet associated progression were identified and confirmed by using microarray mRNA expression and quantitative RTPCR. Next, we focused on the TWEAK-Fn14 signal system as a target. We found that the TWEAK-Fn14 signal promote invasion and progression of prostate cancers in vitro and in clinical settings.
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[Journal Article] Relationship Between Bone Mineral Density and Androgen-deprivation Therapy in Japanese Prostate Cancer Patients2010
Author(s)
Yuasa T, Maita S, Tsuchiya N, Ma Z, Narita S, Horikawa Y, Yamamoto S, Yonese J, Fukui I, Takahashi S, Hatake K, Habuchi T.
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Journal Title
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[Journal Article] Cystoprostatectomy as a treatment of prostate cancer involving the bladder neck2009
Author(s)
Kumazawa T, Tsuchiya N, Saito M, Inoue T, Narita S, Horikawa Y, Yuasa T, Satoh S, Kato T, Nanjyo H, Habuchi T.
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Journal Title
Urol Int. 83(2)
Pages: 141-5
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[Journal Article] Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer2009
Author(s)
Tsuchiya N, Narita S, Kumazawa T, Inoue T, Ma Z, Tsuruta H, Saito M, Horikawa Y, Yuasa T, Satoh S, Ogawa O, Habuchi T.
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Journal Title
Oncol Rep. 22(3)
Pages: 493-9
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[Journal Article] The novel tumor-suppressor Mel-18 in prostate cancer : Its functional polymorphism, expression, and clinical significance2009
Author(s)
Wang W, Yuasa T, Tsuchiya N, Ma Z, Maita S, Narita S, Kumazawa T, Inoue T, Tsuruta H, Horikawa Y, Saito M, Hu W, Ogawa O, Habuchi T.
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Journal Title
Int J Cancer 125(12)
Pages: 2836-43
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[Journal Article] Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells2009
Author(s)
Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SM, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, Fukuda MN
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Journal Title
Proc Natl Acad Sci USA 106(9)
Pages: 3095-100
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[Journal Article]2009
Author(s)
Okamoto A, Yamamoto H, Imai A, Hatakeyama S, Iwabuchi I, Yoneyama T, Hashimoto Y, Koie T, Kamimura N, Mori K, Yamaya K, Ohyama C.
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Journal Title
Oncol Rep. 21(1)
Pages: 73-9
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[Journal Article] Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population2008
Author(s)
Ma Z, Tsuchiya N, Yuasa T, Inoue T, Kumazawa T, Narita S, Horikawa Y, Tsuruta H, Obara T, Saito M, Satoh S, Ogawa O, Habuchi T.
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Journal Title
Int J Cancer 123(11)
Pages: 2574-2579
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[Journal Article] Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis2008
Author(s)
Inoue-Narita T, Hamada K, Sasaki T, Hatakeyama S, Fujita S, Kawahara K, Sasaki M, Kishimoto H, Eguchi S, Kojima I, Beermann F, Kimura T, Osawa M, Itami S, Mak TW, Nakano T, Manabe M, Suzuki A.
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Journal Title
Cancer Res. 68(14)
Pages: 5760-8
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[Journal Article] Bone mineral density in Japanese prostate cancer patients under androgen-deprivation therapy2008
Author(s)
Wang W, Yuasa T, Tsuchiya N, Maita S, Kumazawa T, Inoue T, Saito M, Ma Z, Obara T, Tsuruta H, Satoh S, Habuchi T.
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Journal Title
Endocr Relat Cancer 15(4)
Pages: 943-52
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[Journal Article] Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer2008
Author(s)
Tsuchiya N, Inoue T, Narita S, Kumazawa T, Saito M, Obara T, Tsuruta H, Horikawa Y, Yuasa T, Satoh S, Habuchi T.
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Journal Title
J Urol. 180(6)
Pages: 2389-95
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[Journal Article] A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer2008
Author(s)
Narita N, Yuasa T, Tsuchiya N, Kumazawa T, Narita S, Inoue T, Ma Z, Saito M, Horikawa Y, Satoh S, Ogawa O, Habuchi T.
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Journal Title
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[Journal Article] Prospective Evaluation of Selection Criteria for Active Surveillance in Japanese Patients with Stage T1cN0M0 Prostate Cancer2008
Author(s)
Kakehi Y, Kamoto T, Shiraishi T, Ogawa O, Suzukamo Y, Fukuhara S, Saito Y, Tobisu KI, Kakizoe T, Shibata T, Fukuda H, Akakura K, Suzuki H, Shinohara N, Egawa S, Irie A, Sato T, Maeda O, Meguro N, Sumiyoshi Y, Suzuki T, Shimizu N, Arai Y, Terai A, Kato T, Habuchi T, Fujimoto H, Niwakawa M.
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Journal Title
Jpn J Clin Oncol 38(2)
Pages: 122-8
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[Journal Article] Prognostic significance of HIF-1alpha polymorphisms in transitional cell carcinoma of the bladder2008
Author(s)
Nadaoka J, Horikawa Y, Saito S, Kumazawa T, Inoue T, Narita S, Yuasa T, Satoh S, Nishiyama H, Ogawa O, Tsuchiya N, Habuchi T.
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Journal Title
Int J Cancer 122(6)
Pages: 1297-302
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[Journal Article] Possible survival benefit of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin combination therapy (HD-MVAC) over conventional MVAC in metastatic urothelial carcinoma patients2007
Author(s)
Inoue T, Obara T, Saito M, Kumazawa T, Yuasa T, Matuura S, Tsuchiya N, Satoh S, Habuchi T.
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Journal Title
Hinyokika Kiyo. 53(9)
Pages: 613-8
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[Journal Article] Clinical implication of vascular endothelial growth factor T-460C polymorphism in the risk and progression of prostate cancer2007
Author(s)
Fukuda H, Tsuchiya N, Narita S, Kumazawa T, Horikawa Y, Inoue T, Saito M, Yuasa T, Matsuura S, Satoh S, Ogawa O, Habuchi T.
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Journal Title
Oncol Rep. 18(5)
Pages: 1155-63
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[Journal Article] Low concentrations of the histone deacetylase inhibitor, depsipeptide, enhance the effects of gemcitabine and docetaxel in hormone refractory prostate cancer cells2007
Author(s)
Kanzaki M, Kakinuma H, Kumazawa T, Inoue T, Saito M, Narita S, Yuasa T, Tsuchiya N, Habuchi T.
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Journal Title
Oncol Rep. 17(4)
Pages: 761-7
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