The assessment using Positron Emission Tomography in conditionally replicating adenovirus therapy.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390420
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Hyogo College of Medicine
• Principal Investigator: GOTOH Akinobu Hyogo College of Medicine, 医学部, 教授 (70283885)
• Co-Investigator(Kenkyū-buntansha): TERAO Shuuji 兵庫医科大学, 医学部, 助教 (10457103) ; KUBO Shuji 兵庫医科大学, 医学部, 助教 (10441320)
• Co-Investigator(Renkei-kenkyūsha): SENDA Michio 先端医療振興財団, 先端医療センター, 研究所副所長 (00216558) ; TOMINAGA Hideyuki 先端医療振興財団, 先端医療センター, 研究員 (00393348)
• Project Period (FY): 2007 – 2009
• Keywords: 前立腺癌 / 遺伝子治療 / PET

Research Abstract

In this study, we demonstrated the possibility of assessment using Positron Emission Tomography for prostate cancer model received conditionally replicating adenovirus therapy.

Research Products

• [Journal Article] Adenovirus vector production using low-multiplicity infection of 293 cells (2009)
  • Author(s): Yamada K, Morishita N, Katsuda T, Kubo S, Gotoh A, Yamaji H
  • Journal Title: Cytotechnology 59巻 Pages: 153-60
  • Peer Reviewed
• [Journal Article] A pilot study of quality of life of patients with hormone-refractory prostate cancer after gene therapy (2009)
  • Author(s): Terao S, Gotoh A., et al
  • Journal Title: Anticancer Res 29巻 Pages: 1533-7
  • Peer Reviewed
• [Journal Article] Improved gene transfer into renal carcinoma cells using adenovirus vector containing RGD motif (2009)
  • Author(s): Terao S, Acharya B, Suzuki T, Aoi T, Naoe M, Hamada K, Mizuguchi H, Gotoh A
  • Journal Title: Anticancer Res 29巻 Pages: 2997-3001
  • Peer Reviewed
• [Journal Article] Long-term outcome of phase I/II clinical trial of Ad-OC-TK/VAL gene therapy for hormone-refractory metastatic prostate cancer (2007)
  • Author(s): Shirakawa, T., Terao, S., Gotoh, A., et al.(18名中18番目)
  • Journal Title: Hum. Gene Ther 18巻 Pages: 1225-1232
  • Peer Reviewed
• [Journal Article] 前立腺癌-基礎・臨床研究のアップデート-, 前立腺癌に対する遺伝子治療の現状と展望 (2007)
  • Author(s): 後藤章暢, 寺尾秀治, 白川利朗
  • Journal Title: 日本臨牀 65巻(増刊10) Pages: 517-521
• [Presentation] ヒト膀胱癌細胞株に対するIAI. 3Bプロモーターを組み込んだ制限増殖型アデノウイルスベクターの有用性の検討 (2009)
  • Author(s): 寺尾秀治, Acharya B, 鈴木透, 濱田雄行, 後藤章暢
  • Organizer: 第59回日本泌尿器科学会中部総
  • Place of Presentation: 金沢
  • Year and Date: 2009-10-30
• [Presentation] Improved gene transfer into renal carcinoma cells using an adenovirus vector (2009)
  • Author(s): Terao S, Acharya B, Suzuki T, Gotoh A
  • Organizer: The 19th Annual Meeting of the International Urological Conference of Taiwan
  • Place of Presentation: Kaohsiung
  • Year and Date: 2009-08-29
• [Presentation] Therapeutic efficacy of midkine promoter-based conditionally replicative adenovirus vector for targeting the midkine-expressing human bladder cancer cells (2008)
  • Author(s): Terao, S., Shirakawa, T., Tanaka, K., Takenaka, A., Kamidono, S., Fujisawa, M., Gotoh, A
  • Organizer: American Urological Association 2008 Annual Meeting (AUA2008)
  • Place of Presentation: Orlando. U.S. A
  • Year and Date: 2008-05-20
• [Presentation] 後藤章暢、内分泌療法抵抗性前立腺癌骨転移巣及び局所再発巣に対するAd-OC-TK/VAL遺伝子治療の第I/II相臨床試験 (2007)
  • Author(s): 寺尾秀治, 白川利朗, 日向信行, 田中一志, 武中篤, 藤澤正人
  • Organizer: 第23回前立腺シンポジウ
  • Place of Presentation: 東京
  • Year and Date: 2007-12-09
• [Book] 第2部ゲノム医療の実践に向けて第5章遺伝子治療A:(総論)遺伝子治療-歴史と背景-, B:(各論1)前立腺がんの遺伝子治療
  • Author(s): 後藤章暢
  • Total Pages: A:260-4、B:265-71
  • Publisher: 六然社