2009 Fiscal Year Final Research Report
Evidence for an epigenetic mechanisms in ovarian cancer by the whole-genome tiling array system.
| Project/Area Number |
19390423
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
ARIMA Takahiro Tohoku University, 未来医工学治療開発センター, 准教授 (80253532)
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| Co-Investigator(Kenkyū-buntansha) |
YAEGASHI Nobuo 東北大学, 大学院・医学系研究科, 教授 (00241597)
CHISAKA Hirosi 東北大学, 病院, 講師 (40323026)
ABE Keiko 東北大学, 未来医工学治療開発センター, 技術補佐員 (30444003)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 卵巣癌 / エピジェネティックス / 症例対照研究 / ChIP-on-Chip / DNAメチル化 / インプリント遺伝子 |
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| Research Abstract |
We examined the epigenetic mechanisms (DNA methylation abnormality) in ovarian cancer by the whole-genome tiling array system and analysed the association between the etiology and conditions of a patient (age, staging, histological type). We found early stage variation for some tumor suppressor genes and imprinted genes. From the viewpoint of onset prevention, we examined the environmental factors, such as meals and life-styles. Furthermore, we developed a novel methylation analysis system, PCR-Luminex methods.
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[Journal Article] A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip2010
Author(s)
Hiura H, Sugawara A, Ogawa H, John RM, Miyauchi N, Miyanari Y, Horiike T, Li Y, Yaegashi N, Sasaki H, Kono T, Arima T.
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Journal Title
Nucleic Acids Research (in press)
Peer Reviewed
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