2009 Fiscal Year Final Research Report
Molecular mechanisms on differentiation or function of osteoblasts and osteoclasts by the Wnt/LRP signaling pathway
| Project/Area Number |
19390469
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAMURA Masato Hokkaido University, 大学院・歯学研究科, 教授 (30236757)
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| Co-Investigator(Kenkyū-buntansha) |
NASHIMOTO Masayuki 新潟薬科大学, 応用生物学部, 教授 (30228069)
NEMOTO Eiji 東北大学, 大学院・歯学研究科, 講師 (40292221)
ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 骨形成 / 骨吸収 / Wntシグナル / 骨芽細胞 |
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| Research Abstract |
In this study, we demonstrated that two cellular signaling pathways of Wnt and bone morphogenetic protein (BMP) control both differentiation and function of osteoblasts and osteoclasts during processes of bone formation and resorption. These Wnt and BMP signaling regulates osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, which can inhibit the production of osteoclasts. The regulation of OPG expression is mediated through two transcription pathways such as Wnt and BMP that involve the OPG promoter. We also demonstrated that osteoblastic differentiation mediated by certain miRNA expression and BMP-2 down-regulates miR-206 expression at the post-transcriptional level and that BMP-2 could regulate miRNA biogenesis by a novel mechanism.
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Research Products
(27 results)
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[Journal Article] Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments2007
Author(s)
Ibi M, Ishisaki A, Yamamoto M, Wada S, Kozakai T, Nakashima A, Iida J, Takao S, Izumi Y, Yokoyama A, Tamura M
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Journal Title
Arch. Oral Biol 52(10)
Pages: 1002-1008
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