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2009 Fiscal Year Final Research Report

A crosstalk between Toll-like receptor and C-type lectin

Research Project

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Project/Area Number 19390477
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHokkaido University

Principal Investigator

SHIBATA Kenichiro  Hokkaido University, 大学院・歯学研究科, 教授 (50145265)

Co-Investigator(Kenkyū-buntansha) HASEBE Akira  北海道大学, 大学院・歯学研究科, 助教 (90281815)
Project Period (FY) 2007 – 2009
Keywords免疫 / 感染 / 炎症
Research Abstract

Hosts recognize microbial invasion and then kill them intracellularily. In this study, we demonstrated that the signal mediated by a sensor that recognize bacterial invasion was suppressed by that by phagocytic receptor.

  • Research Products

    (14 results)

All 2010 2009 2008 2007 Other

All Journal Article (4 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] The TLR2 ligand FSL-1 is internalized via clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR22010

    • Author(s)
      HM Shamsul, A Hasebe, M Iyori, M Ohtani, K Kiura, D Zhang, Y Totsuka, K Shibata
    • Journal Title

      Immunology 130

      Pages: 262-272

  • [Journal Article] A role of the Ca2+ binding site of DC-SIGN in the phagocytosis of E. coli.2008

    • Author(s)
      M Iyori, M Ohtani, A Hasebe, Y Totsuka, K Shibata
    • Journal Title

      Biochem. Biophy. Res. Comm 377(2)

      Pages: 367-372

  • [Journal Article] Resveratrol modulates phagocytosis of bacteria through an NF-κB-dependent gene program2008

    • Author(s)
      M Iyori, H Kataoka, HM Shamsul, K Kiura, T Nakata, A Hasebe, M Yasuda, K Shibata
    • Journal Title

      Antimicrob. Agents. Chemother 52(1)

      Pages: 121-127

  • [Journal Article] The diacylated lipopeptide FSL-1 enhances phagocytosis of bacteria by macrophages through Toll-like receptor 2-mediated signaling pathway2007

    • Author(s)
      M Mae, M Iyori, M Yasuda, HM Shamsul, H Kataoka, A Hasebe, K Kiura, Y Totsuka, K Shibata
    • Journal Title

      FEMS. Immunol. Med. Microbiol 49

      Pages: 398-409

  • [Presentation] 9件)(1)柴田健一郎.マイコプラズマ由来リポタンパク質-リポペプチドのユニークな生物活性2009

    • Author(s)
      柴田健一郎
    • Organizer
      日本マイコプラズマ学会第36回学術集会講演要旨集:27
    • Place of Presentation
      札幌
    • Year and Date
      2009-06-05
  • [Presentation] How is the diacylated lipopeptide FSL-1processed after recognition by TLR2?2009

    • Author(s)
      MS Haque, A Hasebe, M Iyori, K Kiura, M Ohtani, K. Shibata
    • Organizer
      he 96th Annual Meeting of The American Association of Immunologists
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      2009-05-11
  • [Presentation] Downregulation of the TLR2-mediated signal by the DC-SIGN ligand Man-LAM2009

    • Author(s)
      M Ohtani, A Hasebe, M Iyori, MS Haque, Y Totsuka, K Shibata
    • Organizer
      The 96th Annual Meeting of The American Association of Immunologists
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      2009-05-11
  • [Presentation] Anti-and pro-tumor activities of the TLR2 ligand FSL-12009

    • Author(s)
      K Shibata, K Kiura, A Hasebe, M Iyori, MS Haque, M Ohtani
    • Organizer
      The 96th Annual Meeting of The American Association of Immunologists
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      2009-05-09
  • [Presentation] Anti- and pro-tumor activities of the mycoplasmal lipopeptide FSL-1 as a TLR2 ligand. Innate Immunity Symposium2008

    • Author(s)
      Shibata K. Kiura K
    • Organizer
      Regulation in Innate Immunity- from Recognition Molecules to Antimicrobial Peptides
    • Place of Presentation
      Shionogi Innovation Center for drug discovery, Hokkaido University
    • Year and Date
      2008-10-28
  • [Presentation] Toll-like receptor 2シグナルに及ぼすDC-SIGNシグナルの影響(優秀ポスター賞受賞)2008

    • Author(s)
      大谷誠、伊従光洋、長谷部晃、木浦和人、戸塚靖則、柴田健一郎
    • Organizer
      第50回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-24
  • [Presentation] 腫瘍の増殖に及ぼすジアシルリポペプチドFSL-1の影響., 自然免疫の最前線-3学会合同大会2008-2008

    • Author(s)
      木浦和人、柴田健一郎
    • Organizer
      第73回日本インターフェロン・サイトカイン学会学術集会・第19回日本生体防御学会学術総会・第45回補体シンポジウム
    • Place of Presentation
      札幌(北海道大学・学術交流会館)
    • Year and Date
      2008-07-10
  • [Presentation] ジアシルリポペプチドFSL-1による制御性T細胞の増殖と腫瘍免疫応答の抑制2008

    • Author(s)
      木浦和人、長谷部晃、柴田健一郎
    • Organizer
      日本マイコプラズマ学会第35回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-31
  • [Presentation] Toll-like receptor 2とDC-SIGNシグナルのクロストーク2008

    • Author(s)
      大谷誠、伊従光洋、長谷部晃、木浦和人、戸塚靖則、柴田健一郎
    • Organizer
      日本マイコプラズマ学会第35回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
  • [Remarks]

    • URL

      http://www.den.hokudai.ac.jp/saikin/index.html

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Published: 2011-06-18   Modified: 2016-04-21  

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