2009 Fiscal Year Final Research Report
Development of alveolar bone regenerative medicine using regulated autologous cells
| Project/Area Number |
19390497
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Hiroshima University |
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Principal Investigator |
NISHIMURA Masahiro Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 (00294570)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Yukio 広島大学, 大学院・医歯薬学総合研究科, 教授 (10112062)
SADAMORI Shinsuke 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40187167)
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| Research Collaborator |
SAKAI Yuuhiro 株式会社ジーシー, 研究員
SUEHIRO Fumio 広島大学, 大学院・医歯薬学総合研究科
TSUBOI Masahiro 広島大学, 大学院・医歯薬学総合研究科
KAMADA Kohichi 広島大学, 大学院・医歯薬学総合研究科
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| Project Period (FY) |
2007 – 2009
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| Keywords | 再生医療 / 骨再生 / 幹細胞 / 間葉系幹細胞 / 歯槽骨再生 |
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| Research Abstract |
We have studied basic area how to augment alveolar ridge by minimum intervention using autologous alveolar bone derived mesenchymal stem cells (MSC). We successfully collected MSC from alveolar bone and expanded them in vitro. We have found MSC specific gene and osteogenesis marker. We have found that β-tricalcium phosphates as the suitable scaffold combined with MSC for bone augmentation. Taken together、we have found several basic findings for future bone tissue engineering medicine.
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Research Products
(12 results)
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[Journal Article] Identification of mesenchymal stem cell (MSC)-transcription factors by microarray and knockdown analyses2009
Author(s)
Kubo H, Shimizu M, Taya Y, Kawamoto T, Michida M, Kaneko E, Igarashi A, Nishimura M, Segoshi K, Shimazu Y, Tsuji K, Aoba T, Kato Y
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Journal Title
and signature molecule-marked MSC in bone marrow by immunohistochemistry: Genes Cells 14
Pages: 407-424
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