• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

Strategic development of a novel implant system to achieve bone regeneration without cell transplantation

Research Project

  • PDF
Project/Area Number 19390509
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionThe University of Tokyo

Principal Investigator

TAKATO Tsuyoshi  The University of Tokyo, 医学部附属病院, 教授 (90171454)

Co-Investigator(Kenkyū-buntansha) CHIKADU Daichi  東京大学, 医学部附属病院, 講師 (30343122)
OGASAWARA Toru  東京大学, 医学部附属病院, 講師 (20359623)
NISHIYAMA Nobuhiro  東京大学, 大学院・医学系研究科, 准教授
TEI Yuichi  東京大学, 大学院・医学系研究科, 教授
Project Period (FY) 2007 – 2009
Keywords再生医療 / 骨再生 / 人工骨
Research Abstract

This study aims to develop a novel bone regeneration system which helps or substitutes for cell transplantation. Among three pillars for regenerative medicine, we tried to improve two factors : "signal" and "scaffold". The combined use of nano-carriers and biomaterials induced the activation of osteogenic signal in cells around bone defect sites, which enabled bone regeneration without cell transplantation. In addition, we developed a technique for three-dimensional imaging followed by rapid prototyping to generate tailor-made artificial bone that fitted into defect sites.

  • Research Products

    (35 results)

All 2009 2008 2007 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (14 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Bone regeneration within a tailor-made tricalcium phosphate bone implant with both horizontal and vertical cylindrical holes transplanted into the skull of dogs2009

    • Author(s)
      Choi SJ, Lee JI, Igawa K, Sugimori O, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N.
    • Journal Title

      J Artif Organs 12(4)

      Pages: 274-74

    • Peer Reviewed
  • [Journal Article] Maxillofacial reconstruction using custom-made artificial bones fabricated by inkjet printing technology2009

    • Author(s)
      Saijo H, Igawa K, Kanno Y, Mori Y, Kondo K, Shimizu K, Suzuki S, Chikazu D, Iino M, Anzai M, Sasaki N, Chung UI, Takato T.
    • Journal Title

      J Artif Organs 12(3)

      Pages: 200-5

    • Peer Reviewed
  • [Journal Article] Unilateral expansion of a narrow mandibular dental arch combined with bimaxillary osteotomies in a patient with hypoglossia2009

    • Author(s)
      Mori Y, Susami T, Chikazu D, Saijo H, Sakiyama M, Matsuzaki M, Abe M, Wada M, Iino M, Takato T.
    • Journal Title

      Int J Oral Maxillofac Surg. Jun ; 38(6)

      Pages: 689-93

    • Peer Reviewed
  • [Journal Article] Identification of genes targeted by CpG island methylator phenotype in neuroblastomas, and their possible integrative involvement in poor prognosis2008

    • Author(s)
      Abe M., Watanabe N., McDonell N., Takato T., Ohira M., Nakagawara A., Toshikazu Ushijima
    • Journal Title

      Oncology

    • Peer Reviewed
  • [Journal Article] A case of tumoural calcinosis in the temporomandibular joint associated with systemic sclerosis2008

    • Author(s)
      Chikazu D., Mori Y., Saijo H., Fujihara H., Ko E. C., Hikiji H., Yonehara Y., Takato T.
    • Journal Title

      Int J Oral Maxillofac Surg 37(2)

      Pages: 190-193

    • Peer Reviewed
  • [Journal Article] Intraoral reconstruction of the soft palate following tumor resection using a mucoperiosteal flap supplied by the greater palatine vessels2008

    • Author(s)
      Chikazu D., Mori Y., Saijo H., Hasegawa Y., Fujihara H., Suenaga H., Ko EC., Yonehara Y., Takato T.
    • Journal Title

      Asian J Oral Maxillofac Surg 19

      Pages: 203-206

    • Peer Reviewed
  • [Journal Article] Development of high-throughput screening system for osteogenic drugs using a cell-based sensor2008

    • Author(s)
      Hojo H., Igawa K., Ohba S., Yano F., Nakajima K., Komiyama Y., Ikeda T., Lichtler AC., Woo JT., Yonezawa T., Takato T., Chung UI.
    • Journal Title

      Biochem Biophys Res Commun 14 ; 376 (2)

      Pages: 375-9

    • Peer Reviewed
  • [Journal Article] Patchedl haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity2008

    • Author(s)
      Ohba, S., Kawaguchi, H., Kugimiya, F., Ogasawara, T., Kawamura, N., Saito, T., Ikeda, T., Fujii, K., Miyajima, T., Kuramochi, A., Miyashita, T., Oda, H., Nakamura, K., Takato, T., Chung, U.I.
    • Journal Title

      Dev Cell 14

      Pages: 689-69

    • Peer Reviewed
  • [Journal Article] Metastasis of prostate cancer to the mandibular condyle2008

    • Author(s)
      Saijo H., Chikazu D., Mori Y., Hikiji H., Yonehara Y., Takato T.
    • Journal Title

      Asian J Oral Maxillofac Surg 20

      Pages: 86-88

    • Peer Reviewed
  • [Journal Article] Clinical application of artificial bone in the maxillofacial region2008

    • Author(s)
      Saijo H., Chung UI., Igawa K., Mori Y., Chikazu D., IinoM., Takato T.
    • Journal Title

      J Artif Organs 11

      Pages: 171-176

    • Peer Reviewed
  • [Journal Article] Marked and Independent Prognostic Significance of The CpG Island Methylator Phenotype in Neuroblastomas2007

    • Author(s)
      Abe M., Westermann F., Nakagawara A., Takato T., Schwab M., Ushijima T.
    • Journal Title

      Cancer Lett 247(2)

      Pages: 253-258

    • Peer Reviewed
  • [Journal Article] Intraoral Reconstruction of soft palate with the greater palatine vessels-supplying mucoperiosteal flap following the resection of the tumor2007

    • Author(s)
      Chikazu D., Mori Y., Saijo H., Hasegawa Y., Fujihara H., Suenaga H., Ko E. C, Yonehara Y., Takato T.
    • Journal Title

      Asian J. Oral Maxillofac. Surg. 19 (4)

      Pages: 203-206

    • Peer Reviewed
  • [Journal Article] Yonehara Cyclooxygenase-2 activity is essential for the osseointegration of dental implants2007

    • Author(s)
      Chikazu D., Tomizuka K., Ogasawara T., Saijo H., Koizumi T., Mori Y.
    • Journal Title

      Int.J.Oral.Maxillofac.Surg. 36

      Pages: 441-446

    • Peer Reviewed
  • [Journal Article] Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles2007

    • Author(s)
      Itaka K., Ohba S. (co-first), Miyata K., Kawaguchi H., Nakamura K., Takato T., Chung U.I., Kataoka K.
    • Journal Title

      Mol Ther 15(9)

      Pages: 1655-1662

    • Peer Reviewed
  • [Journal Article] Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor2007

    • Author(s)
      Ohba S., Ikeda T., Kugimiya F., Yano F., Lichtler A. C., Nakamura K., Takato T., Kawaguchi H., Chung U. I.
    • Journal Title

      FASEB J 21(8)

      Pages: 1777-1787

    • Peer Reviewed
  • [Journal Article] A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner2007

    • Author(s)
      Ohba S., Nakajima K., Komiyama Y., Kugimiya F., Igawa K., Itaka K., Moro T., Nakamura K., Kawaguchi H., Takato T., Chung U. I.
    • Journal Title

      Biochem Biophys Res Commun 357(4)

      Pages: 854-860

    • Peer Reviewed
  • [Presentation] 3次元有限要素解析によるインクジェットプリンタを用いた人工骨の構造最適化2009

    • Author(s)
      井川和代, 西條英人, 菅野勇樹, 近津大地, 飯野光喜, 森良之鄭雄一, 高戸毅, 何建梅
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター, 北海道
    • Year and Date
      20091009-20091011
  • [Presentation] カスタムメイド人工骨移植後の移植位置評価2009

    • Author(s)
      菅野勇樹, 西條英人, 井川和代, 大久保和美, 近津大地, 森良之, 飯野光喜, 鄭雄一, 高戸毅
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター, 北海道
    • Year and Date
      20091009-20091011
  • [Presentation] Cyclooxygenase-2は膜性骨の骨折治癒における key factor である2009

    • Author(s)
      近津大地, 藤川由美子, 末永英之, 杉山円, 古賀陽子, 阿部雅修, 西條英人, 森良之, 飯野光喜, 高戸毅
    • Organizer
      第54回日本口腔外科学会総会
    • Place of Presentation
      札幌コンベンションセンター, 北海道
    • Year and Date
      20091009-20091011
  • [Presentation] Finite Element Analysis of The Chin Augmentation Using Custom-Made Tricalcium Phosphate Implant2009

    • Author(s)
      Igawa K, Takato T, Yamamoto K, Suzuki S, Chung UI, He J.
    • Organizer
      11th ESPRAS Congress
    • Place of Presentation
      Rhodes, Greece
    • Year and Date
      20090920-20090926
  • [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice2008

    • Author(s)
      Chikazu D., Taguchi T., Koyama H., Hikiji H.., Fujihara H., Suenaga H., Saijo H., Mori Y., Iino M., Takato T.
    • Organizer
      8th Asian Congress on Oral and Maxillofacial Surgery
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      20081103-20081107
  • [Presentation] Development of high-throughput screening system for osteogenic drugs using cell-based sensor2008

    • Author(s)
      Hojo H., Igawa K., Ohba S., Yano F., Nakajima N., Komiyama K., Ikeda T., Lichtler AC., Woo JT., Yonezawa Y, Takato T., Chung UI.
    • Organizer
      30th annual meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal, Quebec, Canada
    • Year and Date
      20080912-20080916
  • [Presentation] Development of Mini-Tetrapod Bone Fillers2008

    • Author(s)
      Igawa K., Tomizuka K., Choi S., Yamamoto K., Takato T., Sasaki N., Chung U.I.
    • Organizer
      86th General Session & Exhibition of the IADR
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      20080628-20080701
  • [Presentation] 下顎骨半側切除後のプレート再建に三次元立体モデルによりシミュレーションを施行した1例2008

    • Author(s)
      菅野勇樹, 西條英人, 森良之, 末永英之, 山田陽子, 前田祐二郎, 近津大地, 飯野光喜, 高戸毅
    • Organizer
      第62回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      20080417-20080418
  • [Presentation] A Novel Method for Designing Custom-made Artificial Bones2007

    • Author(s)
      Kanno Y., Saijo H., Kondo K., Mori Y., Chikazu D., Yonehara Y., Chun U.I., Takato T.
    • Organizer
      TERMIS-AP
    • Place of Presentation
      Tokyo
    • Year and Date
      20071203-20071205
  • [Presentation] Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer2007

    • Author(s)
      Igawa K., Mochizuki M., Sugimori O., Shimizu K., Yamazawa K., Kawaguchi H., Nakamura K., Takato T., Nishimura R., Suzuki S., Anzai M., Chung U.I., Sasaki N.
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Artificial Organs and the 2nd Meeting of the International Federation for Artificial Organs
    • Place of Presentation
      Osaka
    • Year and Date
      20071028-20071031
  • [Presentation] Application of Custom-made Artificial Bones in the Maxillofacial Region2007

    • Author(s)
      Saijo H., Tei Y., Mori Y., Suenaga H., Chikazu D., Yonehara Y., Takato T.
    • Organizer
      AAOMS 89th Annual Meeting, Scientific Sessions & Exhibition In conjunction with the JSOMS and KAOMS
    • Year and Date
      20071008-20071013
  • [Presentation] 三次元積層造形法によるカスタムメイド人工骨の作成法2007

    • Author(s)
      菅野勇樹, 西條英人, 末永英之, 近津大地, 森良之, 米原啓之, 高戸毅
    • Organizer
      第52回日本口腔外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20070929-20070930
  • [Presentation] 顎顔面領域におけるカスタムメイド人工骨の応用2007

    • Author(s)
      西條英人, 鄭雄一, 森良之, 末永英之, 菅野勇樹, 近津大地, 米原啓之, 高戸毅
    • Organizer
      第52回日本口腔外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20070929-20070930
  • [Presentation] Patched1機能不全による Hedgehog シグナルの活性化は, Runx2のDNA結合・転写活性を競合阻害している抑制型Gli3産生を低下させることによって骨量を増加させる2007

    • Author(s)
      大庭伸介, 藤井克則, 宮島剛, 倉持朗, 宮下俊之, 織田弘美, 中村耕三, 高戸毅, 川口浩, 鄭雄一
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      20070719-20070721
  • [Book] Tissueengineering of bone and cartilage(IBMS Bone Key)2009

    • Author(s)
      Ohba S, Yano F, Chung U.
    • Total Pages
      405-419
  • [Book] 日本口腔外科学会雑誌(各社のインプラントとその特徴)2009

    • Author(s)
      西條英人
    • Total Pages
      330-340
  • [Book] 日本口腔外科学会雑誌(再建下顎におけるインプラント治療)2009

    • Author(s)
      高戸毅, 西條英人
    • Total Pages
      324-329
  • [Book] 再生医療の現状-医工連携の立場から-(日本学術会議、学術の動向)2009

    • Author(s)
      高戸毅
    • Total Pages
      44-47
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/~oralsurg/

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi