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2009 Fiscal Year Final Research Report

RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases

Research Project

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Project/Area Number 19390535
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

YOSHIE Hiromasa  Niigata University, 医歯学系, 教授 (20143787)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Tetsuo  新潟大学, 医歯学総合病院, 准教授 (00215344)
NARITA Ichiei  新潟大学, 医歯学系, 教授 (20272817)
KUBOTA Takehiko  新潟大学, 医歯学総合病院, 講師 (50303136)
Project Period (FY) 2007 – 2009
Keywords歯周炎 / 膠原病 / リスク遺伝子 / RNA発現 / プロテオーム
Research Abstract

本研究では、歯周病と膠原病の感受性に関わる共通遺伝子を解明し、感受性に関連した歯肉組織中のRNA発現と好中球におけるタンパクを同定することを目的とした。解析の結果、歯周炎・膠原病患者のFc受容体、インターロイキン1,6の関連が明確となり、また好中球産生タンパクとしてシトルリン化変換酵素タンパクの発現亢進、さらに歯周炎歯肉組織での共通変動遺伝子発現が同定された。

  • Research Products

    (16 results)

All 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010

    • Author(s)
      Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
    • Journal Title

      J. Periodontol (in press)

    • Peer Reviewed
  • [Journal Article] Genetic risk factors for periodontitis in a Japanese population2009

    • Author(s)
      Kobayashi T, Nagata T, Murakami S, Takashiba S, Kurihara H, Izumi Y, Numabe Y, Watanabe H, Kataoka M, Nagai A, Hayashi J, Ohyama H, Okamatsu Y, Inagaki Y, Tai H, Yoshie H
    • Journal Title

      J Dent Res 88(12)

      Pages: 1137-1141

    • Peer Reviewed
  • [Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults2009

    • Author(s)
      Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, Sumida T, Yoshie H
    • Journal Title

      Periodontol 80(5)

      Pages: 792-799

    • Peer Reviewed
  • [Journal Article] Mannose binding lectin gene polymorphism and the severity of chronic periodontitis2009

    • Author(s)
      Tsutsumi A, Kobayashi T, Ito S, Goto D, Matsumoto I, Yoshie H, Sumida T
    • Journal Title

      Jpn. J. Clin. Immunol 32(1)

      Pages: 48-52

    • Peer Reviewed
  • [Journal Article] Assessment of chromosome 19 for genetic association in severe chronic periodontitis2009

    • Author(s)
      Tabeta K, Shimada Y, Tai H, Ishihara Y, Noguchi T, Soga Y, Takashiba S, Suzuki G, Kobayashi T, Oka A, Kobayasi T, Yamazaki K, Inoko H, Yoshie H
    • Journal Title

      J. Periodontol 80(4)

      Pages: 663-671

    • Peer Reviewed
  • [Journal Article] Lower antibody response to Porphyromonas gingivalis associated with immunoglobulin G Fcgamma receptor IIB polymorphism2008

    • Author(s)
      Honma Y, Sugita N, Kobayashi T, Abiko Y, Yoshie H
    • Journal Title

      Periodotnt Res 43(6)

      Pages: 706-711

    • Peer Reviewed
  • [Journal Article] Association of interleukin-1 receptor anatagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method2008

    • Author(s)
      Komatsu Y, Galicia JC, Kobayashi T, Yamazaki K, Yoshie H
    • Journal Title

      Int. J. Immunogenet 35(2)

      Pages: 165-170

    • Peer Reviewed
  • [Journal Article] Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue2008

    • Author(s)
      Kubota T, Itagaki M, Oshino C, Nagata M, Morozumi T, Kobayashi T, Takagi R, Yoshie H
    • Journal Title

      J. Periodontol 79(1)

      Pages: 166-173

    • Peer Reviewed
  • [Journal Article] The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis2007

    • Author(s)
      Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, Sumida T, Gejyo F, Yoshie H
    • Journal Title

      J. Periodontol 78(12)

      Pages: 2311-2318

    • Peer Reviewed
  • [Journal Article] The FcgammaRIIa polymorphism influences production of interleukin-1 by mononuclear cells. Int2007

    • Author(s)
      Yamamoto K, Kobayashi T, Sugita N, TaiH, Yoshie H
    • Journal Title

      J. Immunogenet 34(5)

      Pages: 369-372

    • Peer Reviewed
  • [Presentation] 関節リウマチ活動度と歯周疾患重症度との関連性2009

    • Author(s)
      小林哲夫
    • Organizer
      日本歯科保存学会2009年度秋季学術大会(第131回)
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-30
  • [Presentation] 歯周炎感受性に関わる好中球FcgammaRIIIb遺伝子多型のプロテオーム解析2009

    • Author(s)
      横山智子
    • Organizer
      第52回秋季日本歯周病学会学術大会
    • Place of Presentation
      宮崎
    • Year and Date
      2009-10-11
  • [Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型2009

    • Author(s)
      小林哲夫
    • Organizer
      第52回春季日本歯周病学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2009-05-15
  • [Presentation] Gene Polymorphisms in Rheumatoid Arthritis and Periodontitis in Japanese2008

    • Author(s)
      Kobayashi T
    • Organizer
      The 4th Pan European Federation of International Association for Dental Research
    • Place of Presentation
      London
    • Year and Date
      2008-09-11
  • [Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis2007

    • Author(s)
      KobayashiT
    • Organizer
      The 93rd. Annual Meeting of the Aerican Academy of Periodontology
    • Place of Presentation
      Washington DC
    • Year and Date
      2007-10-29
  • [Book] Preventive Periodontology臨床を支えるサイエンスを知る、唾液検査を活用する、生活習慣病を予防する2007

    • Author(s)
      小林哲夫、吉江弘正
    • Total Pages
      161-164
    • Publisher
      医歯薬出版

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

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