2009 Fiscal Year Final Research Report
Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator
| Project/Area Number |
19390539
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
TAKAHASHI Nobuhiro Tohoku University, 大学院・歯学研究科, 教授 (60183852)
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| Co-Investigator(Kenkyū-buntansha) |
HANADA Nobuhiro 鶴見大学, 歯学部, 教授 (70180916)
KOSEKI Takeyoshi 東北大学, 大学院・歯学研究科, 教授 (80291128)
SENPUKU Hidenobu 国立感染症研究所, 細菌第一部, 室長 (20250186)
SATO Takuichi 東北大学, 大学院・歯学研究科, 講師 (10303132)
SAKAMOTO Mitsuo 独立行政法人理化学研究所, 微生物材料開発室, 協力研究員 (50321766)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 歯学 / バイオフィルム / メタボローム / 微生物 |
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| Research Abstract |
Metabolome analysis for the representative plaque bacteria and human oral biofilm using a capillary electrophoresis equipped with a time-of-flight mass spectrometer was established. By this method, a new finding was obtained about the pentose-phosphate pathway and the Kreb's tricarboxylic acid cycle, as well as the Embden-Meyerhof-Parnas pathway. In addition, the metabolome analysis was applicable to a very small amount of oral biofilm. These results suggest that the metabolome data can be used as an indicator of oral health status.
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Research Products
(79 results)
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[Remarks] ホームページ等
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[Patent(Industrial Property Rights)] バイオフィルム抑制型抗菌性チタン合金2008
Inventor(s)
高橋正敏, 中條和子, 奥野攻, 高橋信博, 菊地聖史, 高田雄京, 佐々木啓一
Industrial Property Rights Holder
高橋正敏, 中條和子, 奥野攻, 高橋信博, 菊地聖史, 高田雄京, 佐々木啓一
Industrial Property Number
特許権特願2008-294012
Filing Date
2008-11-18
