2009 Fiscal Year Final Research Report
Pathological conditions in the elderly oral dryness using saliva biomarkers and gene expression pattern
| Project/Area Number |
19390544
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
MATSUNO Tomonori The Nippon Dental University, 生命歯学部, 准教授 (80199827)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Tazuko 日本歯科大学, 生命歯学部, 教授 (40095138)
OMATA Kazuhiko 日本歯科大学, 生命歯学部, 助教 (00434142)
HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 助教 (20228430)
SUZUKI Tetsuro 国立感染症研究所, ウイルス第2部, 室長 (00250184)
SATOH So 日本歯科大学, 新潟生命歯学部, 教授 (70235357)
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| Project Period (FY) |
2007 – 2009
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| Keywords | ドライマウス(口腔乾燥症) / 唾液分泌障害 / 唾液バイオマーカー / 遺伝子発現変化 / 酸化ストレス / 加齢 / 生活習慣病 / 加齢性病態 |
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| Research Abstract |
This study suggested that the inflammation of salivary glands play a critical role in pathological conditions in the elderly oral dryness. In model animal experiments, we found that Redox related genes, which were expressed characteristically similar to the inflammation related gene, and hyposalivation was correlated with oxidative stress of serum and saliva. These results indicated that the inflammation of salivary gland is due to oxidative stress, which is increased with aging and lifestyle disease.
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