2009 Fiscal Year Final Research Report
Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects
| Project/Area Number |
19406004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
TAKANO Mikihisa Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (20211336)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Junya 広島大学, 大学院・医歯薬学総合研究科, 准教授 (20301301)
YUMOTO Ryoko 広島大学, 大学院・医歯薬学総合研究科, 助教 (70379915)
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| Project Period (FY) |
2007 – 2009
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| Keywords | タイ国伝承医薬 / 抗がん作用 |
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| Research Abstract |
In Thailand, many traditional medicines are used for therapy and health promotion. Based on the discussion with colleagues in Thailand, some Thai plant extracts and purified compounds were generously provided. The pharmacological effects of these extracts and compounds were examined ; especially the effects on anticancer drug-resistant tumor cells. It was found that certain extracts potentiated the effect of anticancer effect of the drug, while another extract has potential anticancer effect by itself. These results would provide important information for the development of novel anticancer chemotherapies.
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Research Products
(10 results)
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[Journal Article] Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells.2010
Author(s)
Kawami, M., Yumoto, R., Nagai, J., Junyaprasert, V., Soonthornchareonnon, N., Patanasethanont, D., Sripanidkulchai, B., Takano, M.
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Journal Title
Drug Metab. Pharmacokinet. (in press)
Peer Reviewed
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[Journal Article] Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in human hepatoma cell line HepG2.2009
Author(s)
Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R.
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Journal Title
Drug Metab. Pharmacokinet. 24(5)
Pages: 418-427
Peer Reviewed
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[Journal Article] Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components.2007
Author(s)
Patanasethanont, D., Nagai, J., Matsuura, C., Fukui, K., Sutthanut, K., Sripanidkulchai, B.-o., Yenjai, C., Yumoto, R., Takano, M.
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Journal Title
Eur. J. Pharmacol. 566(1-3)
Pages: 67-74
Peer Reviewed
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