Epidemiological characterization on HIV-1 infection in Thailand and Bangladesh

2010 Fiscal Year Final Research Report

• Project/Area Number: 19406019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Gunma University
• Principal Investigator: HOSHINO Hiroo Gunma University, 大学院・医学研究科, 教授 (00107434)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Nobuaki 群馬大学, 大学院・医学系研究科, 講師 (70261831) ; OOUE Atushi 群馬大学, 大学院・医学系研究科, 講師 (80260107) ; TANAKA Atushi 群馬大学, 大学院・医学系研究科, 助教 (20321953)
• Project Period (FY): 2007 – 2010
• Keywords: HIV-1 / エイズ / コレセプター / 抗酸化剤 / 感染抵抗性

Research Abstract

We have identified new coreceptors that can be used by HIV-1 strains. We established a panel of NP-2 cell lines expressing about 20 HIV/SIV coreceptors including those identified in this project and identified coreceptors frequently used by primary HIV-1 isolates. We have analyzed effects of anti-oxidants, namely green tea extract (GTE) and astaxanthin, on CD4 counts, HIV-1 load and levels of oxidants in Thailand.

Research Products

• [Journal Article] Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human glioma-derived cell line. (2010)
  • Author(s): Jinno-Oue A, Shimizu N, Hamada S, Wada A, Tanaka A, Shinagawa M, Ohtsuki T, Mori T, Saha M N, Hoque A S, Islam S, K.Kogure K, Funayama T, Kobayashi Y, Hoshino H
  • Journal Title: Int J Radiat Oncol Biol Phys 76 Pages: 229-241
  • Peer Reviewed
• [Journal Article] Identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses. (2010)
  • Author(s): Shimizu N, Tanaka A, Jinno-Oue A, Mori T, Ohtsuki T, Hoshino H
  • Journal Title: AIDS Res Human Retroviruses 26 Pages: 321-328
  • Peer Reviewed
• [Journal Article] Neuraminidase enhances the initial steps of human T-cell leukemia virus type 1 replication. (2010)
  • Author(s): Tanaka M, Sun B, Tezuka K, Fujisawa J, Tanaka Y, Hoshino H, Miwa M
  • Journal Title: Microbes Infect 12(2) Pages: 119-125
  • Peer Reviewed
• [Journal Article] CADM1 interacts with Tiam1 and promotes Invasive phenotype of human T-cell leukemia virus Type I-transformed cells and adult T-cell leukemia cells. (2010)
  • Author(s): M Masuda, T Maruyama, T Ohta, A Ito, T Hayashi, K Tsukasaki, S Kamihira, S Yamaoka, H Hoshino, T Yoshida, T Watanabe, EJ Stanbridge Y, Murakami
  • Journal Title: J Biol Chem 285 Pages: 15511-15522
  • Peer Reviewed
• [Journal Article] Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype. (2009)
  • Author(s): Nedellec R, Coetzer M, Shimizu N, Hoshino H, Polonis V R, Morris L, Martensson U E, Binley J, Overbaugh J, Mosier D E
  • Journal Title: J Virol 83 Pages: 8353-8363
  • Peer Reviewed
• [Journal Article] Broad usage spectrum of G protein-coupled receptors as coreceptors by primary isolates of human immunodeficiency virus. (2009)
  • Author(s): Shimizu N, Tanaka A, Oue A, Mori T, Ohtsuki T, Apichartpiyakul C, Uchiumi H, Nojima Y, Hoshino H
  • Journal Title: AIDS 23 Pages: 761-769
  • Peer Reviewed
• [Journal Article] A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as coreceptors for human and simian immunodeficiency viruses. (2008)
  • Author(s): Shimizu N, Tanaka A, Oue A, Mori T, Apichartpiyakul C, Hoshino H
  • Journal Title: J Gen Virol 89 Pages: 3126-3136
  • Peer Reviewed
• [Journal Article] Characterization of a CD4-independent clinical HIV-1 that can efficiently infect human hepatocytes through CXCR4. (2008)
  • Author(s): Xiao P, Usami O, Suzuki Y, Ling H, Shimizu N, Hoshino H, Zhuang M, Ashino Y, Gu H, Hattori T
  • Journal Title: AIDS 22 Pages: 1749-1757
  • Peer Reviewed
• [Journal Article] A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus. (2008)
  • Author(s): Shimizu N, Tanaka A, Mori T, Ohtsuki T, Hoque A, Jinno-Oue A, Apichartpiyakul C, Kusagawa S, Takebe Y, Hoshino H
  • Journal Title: Retrovirology 5 Pages: 52
  • Peer Reviewed
• [Journal Article] Detection of human papillomavirus type 56 in Bowen's disease involving the nail matrix. (2008)
  • Author(s): Shimizu A, Tamura A, Abe M, Motegi S, Nagai Y, Ishikawa O, Nakatani Y, Yamamoto Y, Uezato H, Hoshino
  • Journal Title: Br J Dermatol 158(6) Pages: 1273-9
  • Peer Reviewed
• [Journal Article] Tandem repeats of lactoferrin-derived antihepatitis C virus peptide enhance antiviral activity in cultured human hepatocytes. (2007)
  • Author(s): Abe K, Nozaki A, Tamura A, Ikeda M, Naka K, Dansako H, Hoshino H, Tanaka K, Kato N
  • Journal Title: Microbiol Immunol 51 Pages: 117-125
  • Peer Reviewed
• [Journal Article] CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates. (2007)
  • Author(s): Lauren A, Vincic E, Hoshino H, Thorstensson R, Fenyo EM
  • Journal Title: Retrovirology 4 Pages: 50(1-14)
  • Peer Reviewed
• [Journal Article] Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549).
  • Author(s): T Ishioka, H Kimura, H Kita, M Obuchi, H Hoshino, M Noda, A Nishina, K Kozawa, M Kato
  • Journal Title: Cell Biol Int (in press)
  • Peer Reviewed
• [Presentation] Tax1導入ネコ細胞株における、HTLV-Iの持続感染の成立と合胞体形成 (2010)
  • Author(s): 森隆久、品川雅彦、大上厚志、田中淳、清水宣明、星野洪郎
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-09
• [Presentation] Bowen病におけるhuman papilloma virus感染の検討 (2010)
  • Author(s): 清水晶、中谷陽子、石川治、星野洪郎
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-09
• [Presentation] HIVコレセプター活性を持つGタンパク質共役受容体の分子系統関係の特徴 (2009)
  • Author(s): 清水宣明、Islam Salequl、大上厚志、田中淳、大槻貴博、星野洪郎
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] HTLV-1のcell-free感染を高感度に検出する実験系の確立 (2009)
  • Author(s): 森隆久、品川雅彦、大上厚志、田中淳、清水宣明、星野洪郎
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Incorporation of non-susceptible bystander cells into HIV-1syncytia. (2008)
  • Author(s): Hoque Sk Ariful、大上厚志、田中淳、Islam Salequl、清水宣明、星野洪郎
  • Organizer: 第22回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] シンシチウム形成におけるHTLV-1遺伝子産物Taxの作用 (2008)
  • Author(s): 森隆久、品川雅彦、大上厚志、田中淳、清水宣明、星野洪郎
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2008-10-26
• [Presentation] 重粒子線が細胞のHIV-1感受性におよぼす効果の解析 (2008)
  • Author(s): 清水宣明、大上厚志、田中淳、大槻貴博、和田成一、小林泰彦、星野洪郎
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2008-10-26
• [Presentation] 重粒子線照射ヒトグリオーマ細胞のヒト免疫不全ウイルス1型感受性の亢進 (2008)
  • Author(s): 星野洪郎、清水宣明、大上厚志、田中淳、大槻貴博、和田成一、小林泰彦
  • Organizer: 第12回日本神経ウイルス研究会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2008-07-18
• [Presentation] Broad usage spectrum of G protein-coupled receptors as coreceptors by primary isolates of human immunodeficiency viruses. (2008)
  • Author(s): 清水宣明、大上厚志、田中 淳、大槻貴博、森隆久、Hoque Ariful、Islam Salequl、内海英貴、野島美久、星野洪郎
  • Organizer: 第7回日中ウイルス学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-02
• [Presentation] HIV-1感染感受性に対する重粒子線の効果の解析 (2007)
  • Author(s): 清水宣明、大上厚志、田中淳、大槻貴博、和田成一、小林泰彦、星野洪郎
  • Organizer: 第21回日本エイズ学会
  • Place of Presentation: 広島
  • Year and Date: 2007-11-29
• [Presentation] 重粒子線照射による細胞形質の特徴的変化について-ウイルスを利用した解析 (2007)
  • Author(s): 星野洪郎、清水宣明、大上厚志、田中淳、Saha M.Narayan、Hoque Ariful、品川雅彦、大槻貴博、森隆久、小林泰彦、和田成一、浜田信行、舟山知夫、鳴海一成
  • Organizer: 第50回日本放射線影響学会
  • Place of Presentation: 千葉
  • Year and Date: 2007-11-16
• [Presentation] 色々なG蛋白質共役受容体を発現したヒト細胞を用いたHIV-1感染者末梢血リンパ球からのHIV-1の分離 (2007)
  • Author(s): 清水宣明、大上厚志、田中淳、大槻貴博、森隆久、Hoque Ariful、Islam Salequl、内海英貴、野島美久、星野洪郎
  • Organizer: 第55回日本ウイルス学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-21
• [Presentation] HTILV-I粒子は広範囲の温度において非常に不安定である (2007)
  • Author(s): 品川雅彦、大上厚志、田中淳、清水宣明、星野洪郎
  • Organizer: 第55回日本ウイルス学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-21
• [Presentation] 血液脳関門構成細胞を用いたHIV-1感染実験 (2007)
  • Author(s): 大上厚志、清水宣明、田中淳、大槻貴博、清水晶、小暮公孝、星野洪郎
  • Organizer: 第11回日本神経ウイルス研究会
  • Place of Presentation: 草津
  • Year and Date: 2007-07-06