2009 Fiscal Year Final Research Report
Epidemiological research for the relationship between Helicobacter pylori infection and gastrointestinal diseases in Asia
| Project/Area Number |
19406025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Gastroenterology
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| Research Institution | Kobe University |
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Principal Investigator |
AZUMA Takeshi Kobe University, 医学研究科, 教授 (60221040)
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| Co-Investigator(Kenkyū-buntansha) |
UGA Shoji 神戸大学, 保健学研究科, 教授 (90071399)
YOSHIDA Masaru 神戸大学, 医学研究科, 准教授 (00419475)
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| Project Period (FY) |
2007 – 2009
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| Keywords | H.pylori / 消化器疾患 / 疫学調査 / 感染症 |
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| Research Abstract |
In this study, the pathological conditions in H.pylori infection were analyzed with the molecular epidemiological methods, because those had the problem, so called Ethnical enigma. As a result, it was revealed that the infection of East Asian type CagA positive H.pylori was closely associated with the degree of atrophic gastritis and the development of gastric cancer. In the future, by the personalized eradication therapy for the patients infected with East Asian type CagA positive H.pylori, which is considered to be associated strongly with the development of atrophic gastritis and subsequent gastric cancer, it is expected that the incidence rate of peptic ulcer and gastric cancer might be decreased in Asia
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