2010 Fiscal Year Final Research Report
Pathogenesis of oral cancer due to chewing habits spread in Asia to East Africa
| Project/Area Number |
19406030
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
SAKU Takashi Niigata University, 医歯学系, 教授 (40145264)
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| Co-Investigator(Kenkyū-buntansha) |
CHENG Jun 新潟大学, 医歯学系, 准教授 (40207460)
MARUYAMA Satoshi 新潟大学, 医歯学総合病院, 講師 (30397161)
IDA Hiroko 新潟大学, 医歯学総合病院, 講師 (60293213)
YAMAZAKI Manabu 新潟大学, 医歯学系, 助教 (10547516)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 口腔がん / 噛みタバコ / 発症機構 / 病理疫学 / 分子病理学 |
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| Research Abstract |
Since betel quid chewing in the south Asian area is the most representative causative factor of oral cancer, we surveyed oral cancer cases in Yemen, Jordan, Egypt, Sudan, Morocco, and Myanmar, where different sorts of chewing habits are performed. In those areas, chewing-related oral cancer was shown to be one of the most frequent cancers. Analyzing tissue specimens collected from there, we have established important histopathological diagnostic criteria for carcinoma in-situ and epithelial dysplasia both of which superficial carcinoma is comprised of. Their criteria were scientifically supported in multiple aspects by cell biology-based evidence.
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[Journal Article] Emergence of keratin 17 vs. loss of keratin 13 : Their reciprocal immunohistochemical profiles in oral carcinoma in situ.2011
Author(s)
Mikami T, Cheng J, Maruyama S, Kobayashi T, Funayama A, Yamazaki M, Adeola HA, Wu L, Shingaki S, Saito C, Saku T
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Journal Title
Oral Oncology 47(6)
Pages: 497-503
Peer Reviewed
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[Journal Article] Differential expression of perlecan receptors, α-dystroglycan and integrin β1, before and after invasion of oral squamous cell carcinoma.2011
Author(s)
Ahsan MS, Yamazaki M, Maruyama S, Kobayashi T, Ida-Yonemochi H, Hasegawa M, Adeola HA, Cheng J, Saku T
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Journal Title
Journal of Oral Pathology & Medicine 40(6) in press
Pages: (DOI:10.1111/J.1600-0714.2010.00990.x)
Peer Reviewed
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[Journal Article] Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ : an aid for histopathologic recognition of their cell proliferation centers.2009
Author(s)
Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Mikami T, Alvarado CG, Ahsan MS, Maruyama S, Cheng J, Saku T
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Journal Title
Journal of Oral Pathology & Medicine 38(4)
Pages: 348-355
Peer Reviewed
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