• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2010 Fiscal Year Final Research Report

Genetic study on the oligodontia in Asia

Research Project

  • PDF
Project/Area Number 19406031
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUDA Naoto  Tokyo Medical and Dental University, 歯学部, 教授 (90302885)

Co-Investigator(Kenkyū-buntansha) YAMASHIRO Takashi  岡山大学, 大学院・医歯学総合研究科, 教授 (70294428)
MITOME Masato  徳島大学, ヘルスバイオサイエンス研究部, 教授 (50261318)
FUKUMOTO Satoshi  東北大学, 歯学研究科, 教授 (30264253)
MORIYAMA Keiji  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20262206)
OGAWA Takuya  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50401360)
TSUJI Michiko  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90345281)
Project Period (FY) 2007 – 2010
Keywords先天性多数歯欠損 / 遺伝子変異 / PAX9 / MSX1
Research Abstract

It is known that congenital missing of permanent teeth is one of the most popular anomalies in craniofacial region. Lacking of many teeth (oligodontia) causes serious dysfunction to the mastication, pronounciation and food intake. In this study, we identified a novel gene mutation (321_322insG) in a transcription factor, PAX9. This mutaion was unstable and had a shorter half life than wild-type PAX9.

  • Research Products

    (39 results)

All 2011 2010 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (19 results) Book (4 results)

  • [Journal Article] Familial Non-syndromic Oligodontia with a Novel Frame Shift Mutation of PAX9 is Related to Impaired RNA Stability.2011

    • Author(s)
      Suda N, Ogawa T, Kojima T, Saito C, Moriyama K.
    • Journal Title

      J Dent Res 90

      Pages: 382-386

    • Peer Reviewed
  • [Journal Article] Localization of heat shock protein 27 (hsp27) in the rat gingiva and its changes with tooth eruption.2011

    • Author(s)
      Sasaki A, Yamada T, Inoue K, Momoi T, Tokunaga H, Sakiyama K, Kanegae H, Suda N, Amano O.
    • Journal Title

      Acta Histochem Cytochem 44

      Pages: 17-24

    • Peer Reviewed
  • [Journal Article] Systemic and maxillofacial characteristics of individuals affected by Beckwith-Wiedemann syndrome who have not received a glossectomy.2011

    • Author(s)
      Kawafuji A, Suda N, Suzuki T, Ichikawa N, Kakara S, Baba Y, Ogawa T, Tsuji M, Moriyama K.
    • Journal Title

      Am J Orthod Dentfacial Orthop 139

      Pages: 517-525

    • Peer Reviewed
  • [Journal Article] Dilated capillaries, disorganized collagen fibers and differential gene expression in periodontal ligaments of hypomorphic fibrillin-1 mice.2010

    • Author(s)
      Ganburged G, Suda N, Saito M, Yamazaki Y, Isokawa K, Moriyama K.
    • Journal Title

      Cell Tissue Res 341

      Pages: 381-395

    • Peer Reviewed
  • [Journal Article] Correlation between genotype and supernumerary tooth formation in cleidocranial dysplasia.2010

    • Author(s)
      Suda N, Hattori M, Kosaki K, Banshodani A, Kozai K, Tanimoto K, Moriyama K.
    • Journal Title

      Orthod Craniofac Res 13

      Pages: 197-202

    • Peer Reviewed
  • [Journal Article] A Mongolian patient with hypohidrotic ectodermal dysplasia with a novel P121S variant in EDARADD.2010

    • Author(s)
      Suda N, Bazar A, Bold O, Jigid B, Gardkhuu, A, Ganburged G, Moriyama K.
    • Journal Title

      Orthod Craniofac Res 13

      Pages: 114-117

    • Peer Reviewed
  • [Journal Article] Multidisciplinary management including endodontics, periodontics, orthodontics, anterior maxillary osteotomy and prosthetics in an adult case with a severe openbite.2009

    • Author(s)
      Suda N ; Kawafuji K ; Moriyama K.
    • Journal Title

      Orthod Waves 68

      Pages: 42-49

    • Peer Reviewed
  • [Journal Article] Diagnosis of Russell-Silver syndrome by the combined bisulfate restriction analysis.denatuing high performance liquid chromatography assay.2009

    • Author(s)
      Hattori M, Torii C, Yagihashi T, Izumi K, Suda N, Ohyama K, Takahashi T, Moriyama K, Kosaki K.
    • Journal Title

      Genet Test Mol Biomarkers 13

      Pages: 623-630

    • Peer Reviewed
  • [Journal Article] In vivo application of amelogenin suppresses root resorption.2009

    • Author(s)
      Yagi Y, Suda N, Yamakoshi Y, Baba O, Moriyama K.
    • Journal Title

      J Dent Res 88

      Pages: 176-181

    • Peer Reviewed
  • [Journal Article] Human diseases accompanied with abnormal tooth roots.2009

    • Author(s)
      Suda N. Moriyama K.
    • Journal Title

      Journal of Oral Bioscience 51

      Pages: 199-204

    • Peer Reviewed
  • [Journal Article] Marfan syndrome and its disorder in periodontal tissues.2009

    • Author(s)
      Suda N, Shiga M, Ganburged G, Moriyama K.
    • Journal Title

      J Exp Zoology 312B

      Pages: 1-7

    • Peer Reviewed
  • [Journal Article] Characteristic phenotype of immortalized periodontal cells isolated from a Marfan syndrome type I patient.2008

    • Author(s)
      Shiga M, Saito M, Hattori M, Torii C, Kosaki K, Kiyono T, Suda N.
    • Journal Title

      Cell Tissue Res 331

      Pages: 461-472

    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact.2008

    • Author(s)
      Suda N.
    • Journal Title

      Orthod Craniofac Res 11

      Pages: 1-7

    • Peer Reviewed
  • [Journal Article] Diversity of supernumerary tooth formation in siblings with cleidocranial dysplasia having identical mutation in RUNX2-Possible involvement of non-genetic or epigenetic regulation-2007

    • Author(s)
      Suda N, Hamada T, Hattori M, Torii C, KosakiK, Moriyama K.
    • Journal Title

      Orthod Craniofac Res 10

      Pages: 222-225

    • Peer Reviewed
  • [Journal Article] Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice.2007

    • Author(s)
      Fukuoka H, Shibata S, Suda N, Yamashita Y, Komori T.
    • Journal Title

      J Anat 211

      Pages: 8-15

    • Peer Reviewed
  • [Journal Article] Orthodontic Treatment of a Case of Stickler Syndrome.2007

    • Author(s)
      Suda N, Handa S, Higashihori N, Ogawa T, Tsuji M, Ohyama K.
    • Journal Title

      Angle Orthod 77

      Pages: 931-939

    • Peer Reviewed
  • [Presentation] Marfan症候群のモデルマウスに誘発した歯周疾患に対するAngiotensin II receptor blocker (Telmisartan)の薬理効果2010

    • Author(s)
      須田直人, Ganburged G.
    • Organizer
      第8回エラスチン研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20101203-20101204
  • [Presentation] マルファン症候群の歯周疾患モデルにおけるAngiotensin II receptor blocker (Telmisartan)の薬理効果2010

    • Author(s)
      Ganburged G., 須田直人, 森山啓司
    • Organizer
      第69回日本矯正歯科学会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] Apert症候群型の変異FGFR2(S252W)とその可溶性変異体を過剰発現するトランスジェニックマウスの細胞生物学的解析2010

    • Author(s)
      鈴木尋之, 須田直人, 志賀百年, 谷本幸穂, 中村正孝, 井関祥子, 森山啓司
    • Organizer
      第69回日本矯正歯科学会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] 当分野を受診したDown症候群患者に対する矯正歯科的アプローチ2010

    • Author(s)
      三上智彦, 森田淳平, 大隈瑞恵, 小川卓也、辻美千子, 須田直人, 森山啓司
    • Organizer
      第69回日本矯正歯科学会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] 当分野を受診したDown症候群患者の歯科臨床的特徴について-永久歯の異常に関する検討-2010

    • Author(s)
      大宅彩, 保田裕子, 渡辺千穂, 大隈瑞恵、小川卓也, 辻美千子, 須田直人, 森山啓司
    • Organizer
      第69回日本矯正歯科学会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] 当分野を受診したDown症候群患者の歯科臨床的特徴について-頭蓋顎顔面形態に関する検討-2010

    • Author(s)
      池田倫世, 伊藤洋介, 大隈瑞恵, 小川卓也、辻美千子, 須田直人, 森山啓司
    • Organizer
      第69回日本矯正歯科学会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] PAX9遺伝子に新規フレームシフト型変異を有する先天性多数歯欠損家系の解析2010

    • Author(s)
      須田直人, 小川卓也, 小島拓, 斉藤力, 森山啓司
    • Organizer
      第52回日本歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      20100920-20100922
  • [Presentation] Fibrillin-1 is indispensable for normal collagen fiber architecture and gene expression in periodontal ligament.2010

    • Author(s)
      Suda N,, Ganburged G, Saito M, Yamazaki Y, Isokawa K, Moriyama K.
    • Organizer
      10th Tooth morphogenesis and differentiation
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20100901-20100904
  • [Presentation] Osteoblastic differentiation of transgenic mice overexpressing Apert syndrome-type mutant FGFR2 and its soluble form.2010

    • Author(s)
      Suzuki H, Suda N, Shiga M, Nakamura M, Iseki S, Moriyama K
    • Organizer
      10th Tooth morphogenesis and differentiation
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20100901-20100904
  • [Presentation] Microfibril is essential for normal development of periodontal ligaments (PDLs).2010

    • Author(s)
      Ganburged G, Suda N, Saito M, Yamazaki Y, Isokawa K, Moriyama K.
    • Organizer
      88th General session of Internatinal Association for Dental Research.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20100714-20100717
  • [Presentation] 下顎臼歯部歯槽骨切り術後にLeFort I型骨切り術と下顎枝矢状分割術を施行した下顎狭窄歯列を伴う顔面非対称症例2010

    • Author(s)
      須田直人, 冨永直子, 新中康史, 天笠光雄, 森山啓司
    • Organizer
      第20回日本顎変形症学会総会
    • Place of Presentation
      札幌
    • Year and Date
      20100615-20100616
  • [Presentation] EEC症候群患者における全身および顎顔面・口腔領域の異常に関する検討2010

    • Author(s)
      阿彦希, 須田直人, 辻美千子, 小川卓也, 大隈瑞恵, 福岡裕樹, 岡村絵里花, 鈴木一史, 馬場祥行, 森山啓司
    • Organizer
      第34回口蓋裂学会
    • Place of Presentation
      東京
    • Year and Date
      20100527-20100528
  • [Presentation] 新規細胞外マトリックスであるADAMTSL-5は歯根膜のマイクロフィブリル形成を促進する2009

    • Author(s)
      斉藤正寛, 須田直人, Ganburged G, 辻孝
    • Organizer
      第7回エラスチン研究会学術集会
    • Place of Presentation
      北九州市
    • Year and Date
      20091204-20091205
  • [Presentation] 歯根膜に局在する弾性線維の機能解析に関するアプローチ2009

    • Author(s)
      須田直人, 志賀百年, Ganburged G、斉藤正寛, 山崎洋介, 磯川桂太郎, 森山啓司
    • Organizer
      第7回エラスチン研究会学術集会
    • Place of Presentation
      北九州市
    • Year and Date
      20091204-20091205
  • [Presentation] Differential gene expression in periodontal ligament of mouse model of Marfan syndrome.2009

    • Author(s)
      Ganburged G, Suda N, Saito M, Yamazaki Y, Isokawa K, Moriyama K.
    • Organizer
      第74回口腔病学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      20091204-20091205
  • [Presentation] COBRA-DHPLC法によるラッセルシルバー症候群の遺伝子診断システムの開発2009

    • Author(s)
      服部架, 鳥居千春, 須田直人, 小崎健次郎, 森山啓司
    • Organizer
      第68回日本矯正歯科学会
    • Place of Presentation
      福岡
    • Year and Date
      20091116-20091118
  • [Presentation] 先天性多数歯欠損症患者における永久歯の形成異常に関する報告2009

    • Author(s)
      中澤祐紀, 須田直人, 森山啓司
    • Organizer
      第68回日本矯正歯科学会
    • Place of Presentation
      福岡
    • Year and Date
      20091116-20091118
  • [Presentation] Apert症候群型変異FGFR2とその可溶性変異体を過剰発現するトランスジェニックマウス由来骨芽細胞の解析2009

    • Author(s)
      鈴木尋之, 須田直人, 志賀百年, 井関祥子、森山啓司
    • Organizer
      第51回日本歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      20090909-20090911
  • [Presentation] Apert症候群型変異FGFR2とその可溶性変異体を過剰発現するトランスジェニックマウス由来骨芽細胞の分化形質2009

    • Author(s)
      鈴木尋之, 須田直人, 志賀百年, 中村正孝, 井関祥子, 森山啓司
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      20090723-20090725
  • [Book] 医師・歯科医師のための口腔診療必携-困ったときのマニュアル・ヒント集-(高戸毅監修)東京2010

    • Author(s)
      須田直人
    • Total Pages
      59
    • Publisher
      金原出版
  • [Book] マルファン症候群ガイドブック(沼部博直監修)(歯と歯周組織について)第2版 東京2008

    • Author(s)
      須田直人, 大山紀美栄
    • Total Pages
      168-189
    • Publisher
      マルファンネットワークジャパン
  • [Book] 歯科矯正学(相馬邦道ら編集)(不正咬合の原因(遺伝的要因と環境的要因))第5版 東京2008

    • Author(s)
      須田直人, 森山啓司
    • Total Pages
      85-87
    • Publisher
      医歯薬出版
  • [Book] Characteristic origin and differentiation of condylar cartilage. Ten Cate's Oral histology: Development, Structure and Function, 7th edition (Nanci A, editor)Louis, MO, USA2007

    • Author(s)
      須田直人
    • Total Pages
      361-363
    • Publisher
      Elsevier, St

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi