2008 Fiscal Year Final Research Report
Structural basis for information processing in the synaptic circuit of the olfactory bulb glomeruli
| Project/Area Number |
19500295
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kawasaki Medical School (2008)
The University of Tokushima (2007) |
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Principal Investigator |
TOIDA Kazunori Kawasaki Medical School, 解剖学, 教授 (40253405)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 三次元構造 / 神経回路 / シナプス / 嗅球 / GFP / 介在ニューロン / 電子顕微鏡 |
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| Research Abstract |
We have reported neuronal heterogeneity underlying olfactory information processing in the olfactory bulb glomeruli. By means of combined electrophysiology, light and electron microscopy, bulbar neurons were identified both chemically (by GFP transgenic mice) and morphologically (by Neurolucida). Patch clamp to TH-and GAD-GFP neurons exhibited two types of response to olfactory input, ON-direct and ON-indirect driven types. These finding were confirmed by electron microscopy revealing heterogeneous synaptic contact with special focus on input to then, and suggested elaborate architecture of synaptic circuit based on neuronal heterogeneity chemically, physiologically and morphologically.
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