2010 Fiscal Year Final Research Report
Role of Syntaxin5 isoforms in neuronal cells under ER stress
| Project/Area Number |
19500327
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyorin University |
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Principal Investigator |
SUGA Kei Kyorin University, 医学部, 助教 (30306675)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Ayako 杏林大学, 医学部・その他 (80424109)
MISHIMA Tatsuya 杏林大学, 医学部, 助教 (40317095)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 神経科学 / 脳・神経 / ストレス / 脳神経疾患 / syntaxin |
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| Research Abstract |
The underlying mechanism of how neuronal cells respond to ER stress during the progression of neurodegenerative diseases is poorly understood. We have shown that Syntaxin5 (Syx5) one of the ER-Golgi SNAREs is upregulated under ER stress. The transient upregulation of Syx5 isoforms was observed at the early stages of ER stress response before the cell death pathway have been activated. A subset of ER-Golgi SNAREs was also upregulated by ER stress. These ER-Golgi SNAREs may cooperatively function in the vesicular transport system in neuronal cells.
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