2009 Fiscal Year Final Research Report
Effects of physical training and diet restriction on life-span and insulin resistance in rats
| Project/Area Number |
19500562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Nagoya University |
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Principal Investigator |
OSHIDA Yoshiharu Nagoya University, 総合保健体育科学センター, 教授 (10169295)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 食事療法 / 運動療法 / インスリン感受性 |
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| Research Abstract |
The glycogen content in skeletal muscle of L-Ex (low carbohydrate diet exercise) rats was decreased compared with that of N-Ex (normal chow diet exercise) rats. Taken together, we suggest that the maintenance of glycogen depletion after exercise by continuous low carbohydrate diet results in the increment of the GLUT-4 protein content in skeletal muscle. Moreover, the combination of CR (calorie restriction) and exercise enhanced insulin action in the skeletal muscle of normal animals. Exercise suppressed the fat accumulation and induced Glut-4 protein expression in skeletal muscle, while short-term CR neither suppressed fat accumulation nor induced any changes in insulin signal transduction.
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