2009 Fiscal Year Final Research Report
Oxidative stress- and muscle contraction-stimulated glucose transport in rat skeletal muscle
Project/Area Number |
19500565
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Sports science
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Research Institution | Fukuoka University (2008-2009) Saga University (2007) |
Principal Investigator |
HIGAKI Yasuki Fukuoka University, スポーツ科学部, 准教授 (10228702)
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Project Period (FY) |
2007 – 2009
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Keywords | エネルギー代謝と活性酸素 |
Research Abstract |
Skeletal muscle is an important tissue for glucose homeostasis. Although there are numerous physiological and pharmacological perturbations can increase glucose transport in skeletal muscle, the signaling mechanisms that lead to transport activations are still poorly defined. In the current study, we determined the effects of acute exposure of skeletal muscle to pharmacological agents that produce reactive oxygen spices (ROS) and then assessed potential signaling mechanisms that might mediate the effects of these agents on glucose transport. We found that the acute exposure of muscle to ROS is a potent stimulator of skeletal muscle glucose uptake, and that this occurs though the phosphorylation of AktThr^<308>.
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Research Products
(15 results)
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[Presentation] 身体活動量と耐糖能異常リスクに関する研究2008
Author(s)
桧垣靖樹, 田口尚人, 原めぐみ, 中村和代, 南里妃名子, 今泉猛, 坂本龍彦, 堀田美加子, 新地浩一, 田中恵太郎
Organizer
第18回日本疫学会, 第18回日本疫学会学術総会講演集
Place of Presentation
東京
Year and Date
2008-01-26
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