2009 Fiscal Year Final Research Report
Physiological role of dietary fiber in aging rat
| Project/Area Number |
19500679
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Tokyo Gakugei University |
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Principal Investigator |
MINAMI Michiko Tokyo Gakugei University, 教育学部, 教授 (70272432)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAI Yuji 東京大学, 大学院・農学生命研究科, 特任准教授 (10321788)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 食物繊維 / DNAマイクロアレイ / 遺伝子発現 / 老年期 |
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| Research Abstract |
To determine the physiological role of dietary fiber, 10% and 2% cellulose diet were served 40 weeks male Wister rat for a week. The composition of 12 fecal microflora was analysed by T-RFLP profile derived from the digestion of the fecal 16S rRNA gene by HhaI digestion. The fecal microflora was divided into 2 clusters. Serum PAI-1 is significantly different from 10% and 2% cellulose diet group. The effect of dietary fiber on the gene expression profiles in liver by using DNA microarray analysis.
A gene ontology analysis revealed that lipid metabolic-related genes had been markedly up-regulated.
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Research Products
(6 results)
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[Journal Article] Applocation of Aspergillus saitoi Protease Preparation to Soybean Curd to Modify Its Functional and Rheological Properties Biosci.2008
Author(s)
Mizuho Nishida, Tomiko Asakura, Tomomi Watanabe, Etsuko Kunizaki, Mami Matsumoto, Wakako Eto, Tomoko Tamura, Michik Minami, Akio Obata, Keiko Abe, Junko Funaki
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Journal Title
BIotechnol. Biochem 72(2)
Pages: 581-590
Peer Reviewed
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