2009 Fiscal Year Final Research Report
Is inhibition of thyroid hormone activation involved in methylmercury toxicity in the developing brain?
| Project/Area Number |
19510065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
YOSHIDA Katsumi Tohoku University, 大学院・医学系研究科, 教授 (90166942)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Kouki 東北大学, 大学院・医学系研究科, 准教授 (80301050)
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| Project Period (FY) |
2007 – 2009
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| Keywords | メチル水銀 / 甲状腺ホルモン / 脱ヨード酵素 |
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| Research Abstract |
We examined the association of MeHg toxicity with deiodinases which regulate activation (D2) and inactivation (D3) of thyroid hormone by using cultured rat astrocytes or a human breasy cancer cell line MCF-7. MeHg significantly inhibited D2 and D3 activity. However, it did not affect the expression of D2 and D3 mRNA and protein. These results indicate that MeHg may disturb normal brain development through D2 and D3 inhibition.
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